Distribution patterns of influenza virus receptors and viral attachment patterns in the respiratory and intestinal tracts of seven avian species.
Distribution patterns of influenza virus receptors and viral attachment patterns in the respiratory and intestinal tracts of seven avian species.
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DOI：
10.1186/1297-9716-43-28
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发表时间：
2012-04-10
影响因子：
4.4
通讯作者：
Ramis A
中科院分区：
文献类型：
--
作者：
Costa T;Chaves AJ;Valle R;Darji A;van Riel D;Kuiken T;Majó N;Ramis A
本研究评估了7种鸟类中唾液酸α-2，3和α-2，6连接聚糖受体的存在。用凝集素组织化学方法，对鸡、鹌鹑、红腿凤尾鱼、火鸡、锦鸡、鸵鸟和野鸭的呼吸道和肠道进行了凝集素组织化学研究。此外，使用禽源H4 N5病毒和人源季节性H1N1病毒，用病毒组织化学评价病毒附着模式（PVA）。受体在不同组织和鸟类中的分布差异很大。α-2，3和α-2，6受体均存在于鸡、鹌鹑、红腿鹦鹉、火鸡和锦鸡的呼吸道和肠道中。在鸵鸟的呼吸道和肠道中，α-2，3受体的表达基本上局限于α-2，3受体，而在野鸭的肠道中，α-2，6受体则不表达。用凝集素组织化学法得到的结果一般与PVA法一致。α-2，3和α-2，6受体在不同鸟类中的差异表达和分布可能反映了新病毒株出现的潜在决定性因素。
This study assessed the presence of sialic acid α-2,3 and α-2,6 linked glycan receptors in seven avian species. The respiratory and intestinal tracts of the chicken, common quail, red-legged partridge, turkey, golden pheasant, ostrich, and mallard were tested by means of lectin histochemistry, using the lectins Maackia amurensis agglutinin II and Sambucus nigra agglutinin, which show affinity for α-2,3 and α-2,6 receptors, respectively. Additionally, the pattern of virus attachment (PVA) was evaluated with virus histochemistry, using an avian-origin H4N5 virus and a human-origin seasonal H1N1 virus. There was a great variation of receptor distribution among the tissues and avian species studied. Both α-2,3 and α-2,6 receptors were present in the respiratory and intestinal tracts of the chicken, common quail, red-legged partridge, turkey, and golden pheasant. In ostriches, the expression of the receptor was basically restricted to α-2,3 in both the respiratory and intestinal tracts and in mallards the α-2,6 receptors were absent from the intestinal tract. The results obtained with the lectin histochemistry were, in general, in agreement with the PVA. The differential expression and distribution of α-2,3 and α-2,6 receptors among various avian species might reflect a potentially decisive factor in the emergence of new viral strains.
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影响因子：
11.8
作者：
Mathieu C;Moreno V;Retamal P;Gonzalez A;Rivera A;Fuller J;Jara C;Lecocq C;Rojas M;Garcia A;Vasquez M;Agredo M;Gutiérrez C;Escobar H;Fasce R;Mora J;Garcia J;Fernández J;Ternicier C;Avalos P
通讯作者：
Avalos P
影响因子：
4.8
作者：
Kimble, Brian;Ramirez Nieto, Gloria;Perez, Daniel R.
通讯作者：
Perez, Daniel R.
影响因子：
168.9
作者：
Claas, ECJ;Osterhaus, ADME;Webster, RG
通讯作者：
Webster, RG
影响因子：
4.3
作者：
Guo, Chao-Tan;Takahashi, Noriko;Suzuki, Yasuo
通讯作者：
Suzuki, Yasuo
影响因子：
1.4
作者：
MOHAN, R;SAIF, YM;EASTERDAY, BC
通讯作者：
EASTERDAY, BC