Mycobiota and C-Type Lectin Receptors in Cancers: Know thy Neighbors.
Mycobiota and C-Type Lectin Receptors in Cancers: Know thy Neighbors.
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癌症中的分枝菌群和 C 型凝集素受体：了解你的邻居
DOI：
10.3389/fmicb.2022.946995
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发表时间：
2022
影响因子：
5.2
通讯作者：
Wang, Weixing
中科院分区：
文献类型：
--
作者：
Zhang, Lilong;Chai, Dongqi;Chen, Chen;Li, Chunlei;Qiu, Zhendong;Kuang, Tianrui;Parveena, Mungur;Dong, Keshuai;Yu, Jia;Deng, Wenhong;Wang, Weixing
许多研究已经证明肠道细菌在恶性肿瘤发生发展中的重要性，而对肠道真菌生物群的研究相对较少。作为肠道微生物群的一部分，肠道真菌群的比例与肠道细菌相比微不足道。然而，肠道真菌对人类健康和疾病的影响是显著的。本文系统地综述了头颈癌、食道癌、胃癌、结直肠癌、肝细胞癌、胰腺癌、黑色素瘤、乳腺癌、肺癌恶病质患者肠道真菌的研究进展。此外，我们还首次详细描述了真菌识别受体C型凝集素受体(CLRs)(Dectin-1、Dectin-2、Dectin-3和Mincle)及其下游效应因子caspase募集结构域蛋白9(CARD9)在肿瘤中的作用，为进一步研究肠道真菌在恶性肿瘤诊断和治疗中的作用提供参考。
Numerous studies have demonstrated the importance of gut bacteria in the development of malignancy, while relatively little research has been done on gut mycobiota. As a part of the gut microbiome, the percentage of gut mycobiota is negligible compared to gut bacteria. However, the effect of gut fungi on human health and disease is significant. This review systematically summarizes the research progress on mycobiota, especially gut fungi, in patients with head and neck cancer (HNC), esophageal cancer (EC), gastric cancer (GC), colorectal cancer (CRC), hepatocellular carcinoma (HCC), pancreatic cancer, melanoma, breast cancer, and lung carcinoma-induced cachexia. Moreover, we also describe, for the first time in detail, the role of the fungal recognition receptors, C-type lectin receptors (CLRs) (Dectin-1, Dectin-2, Dectin-3, and Mincle) and their downstream effector caspase recruitment domain-containing protein 9 (CARD9), in tumors to provide a reference for further research on intestinal fungi in the diagnosis and treatment of malignant tumors.
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影响因子：
7.7
作者：
Chiba S;Ikushima H;Ueki H;Yanai H;Kimura Y;Hangai S;Nishio J;Negishi H;Tamura T;Saijo S;Iwakura Y;Taniguchi T
通讯作者：
Taniguchi T
影响因子：
7.3
作者：
Del Fresno C;Iborra S;Saz-Leal P;Martínez-López M;Sancho D
通讯作者：
Sancho D
影响因子：
4.6
作者：
Sung KH;Josewski J;Dübel S;Blankenfeldt W;Rau U
通讯作者：
Rau U
影响因子：
15.9
作者：
Chevalier, Mathieu F.;Trabanelli, Sara;Derre, Laurent
通讯作者：
Derre, Laurent
影响因子：
5.4
作者：
Arce, I;Martínez-Muñoz, L;Fernández-Ruiz, E
通讯作者：
Fernández-Ruiz, E