Basal leg blood flow in healthy women is related to age and hormone replacement therapy status.
Basal leg blood flow in healthy women is related to age and hormone replacement therapy status.
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健康女性的腿部基础血流量与年龄和激素替代治疗状态有关。
DOI：
10.1113/jphysiol.2002.032524
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Seals,DouglasR
中科院分区：
文献类型：
--
作者：
Moreau,KerrieL;Donato,AnthonyJ;Tanaka,Hirofumi;Jones,PamelaParker;Gates,PhillipE;Seals,DouglasR
在健康男性中，下肢基底血流量随年龄增长而下降，这一效应是由交感神经血管收缩增强介导的。然而，在女性中，雌激素的存在或不存在以及选择性使用激素替代疗法（HRT）可能会改变这些与衰老的关系。我们研究了103名健康女性：73名绝经后（41 HRT，平均值±s.e.m.）61 ± 1岁; 32例无HRT，63 ± 2岁）和30例绝经前（29 ± 1岁）。与绝经前对照组相比，绝经后无HRT组的绝对股动脉血流（多普勒超声）降低了23%（P< 0.001），但HRT组仅降低了13%（P< 0.01）。腿部血流的年龄和HRT组差异始终与腿部血管传导性的差异相关，但与股动脉管腔直径、腿部肌肉交感神经活动或心输出量（全身动脉血流量）无关。绝经后组的腿部无脂肪质量较小（P< 0.05）。与绝经前女性相比，绝经后非HRT组的腿部无脂肪质量标准化的股动脉血流降低了17%（P< 0.01），但绝经后HRT组和绝经前组之间没有差异。绝经后HRT组和绝经前女性的股动脉切应力相似，但绝经后未HRT组的股动脉切应力较低（P< 0.01）。在雌激素缺乏的健康女性中，基础全腿血流量随着年龄的增长而下降，这一现象主要由腿部血管传导性的降低介导。在绝经后妇女中，长期使用激素替代疗法与下肢基底血流量和血管传导性增加有关。在长期接受HRT的女性中，腿部无脂肪质量标准化的腿部血流随年龄而保持不变。与男性相比，腿部交感血管收缩神经活动的差异并不能解释女性腿部血流和血管电导随年龄增长的组间差异。
Basal leg blood flow declines with age in healthy men, an effect that is mediated by augmented sympathetic vasoconstriction. However, in women the presence or absence of oestrogen and selective use of hormone replacement therapy (HRT) may alter these relationships with ageing. We studied 103 healthy women: 73 postmenopausal (41 HRT, mean ±s.e.m. 61 ± 1 years; 32 no‐HRT, 63 ± 2 years) and 30 premenopausal (29 ± 1 years). Compared with the premenopausal controls, absolute femoral artery blood flow (duplex ultrasound) was 23 % lower (P< 0.001) in the postmenopausal no‐HRT group, but only 13 % lower in the HRT group (P< 0.01). The age and HRT group differences in leg blood flow were consistently associated with differences in leg vascular conductance, but not with femoral artery lumen diameter, leg muscle sympathetic nerve activity or cardiac output (systemic arterial blood flow). Leg fat‐free mass was smaller in the postmenopausal groups (P< 0.05). Femoral blood flow normalized for leg fat‐free mass was 17 % lower (P< 0.01) in the postmenopausal no‐HRT compared with the premenopausal women, but was not different in the postmenopausal HRT and premenopausal groups. Femoral artery shear stress was similar in the postmenopausal HRT and premenopausal women, but was lower in the postmenopausal no‐HRT group (P< 0.01). Basal whole‐leg blood flow declines with age in healthy, oestrogen‐deficient women, a phenomenon that is mediated primarily by reductions in leg vascular conductance. Among postmenopausal women, chronic HRT use is associated with augmented basal leg blood flow and vascular conductance. Leg blood flow normalized for leg fat‐free mass is preserved with age in women taking chronic HRT. In contrast to men, differences in leg sympathetic vasoconstrictor nerve activity do not explain group differences in leg blood flow and vascular conductance with ageing in women.
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影响因子：
37.8
作者：
D. R. Seals;James M. Hagberg;R. Spina;Marc A. Rogers;Kenneth B. Schechtman;A. Ehsani
通讯作者：
D. R. Seals;James M. Hagberg;R. Spina;Marc A. Rogers;Kenneth B. Schechtman;A. Ehsani
DOI：
10.1016/0002-9149(93)90718-r
发表时间：
1993
期刊：
The American journal of cardiology
影响因子：
--
作者：
R. Spina;T. Ogawa;Tom R. Miller;Wendy M. Kohrt;A. Ehsani
通讯作者：
R. Spina;T. Ogawa;Tom R. Miller;Wendy M. Kohrt;A. Ehsani
3 健康老年人休息和运动时的体温调节
影响因子：
5.7
作者：
W. Kenney
通讯作者：
W. Kenney
影响因子：
8.3
作者：
Sudhir, K;Esler, MD;Komesaroff, PA
通讯作者：
Komesaroff, PA
衰老与冠状动脉内皮基础一氧化氮的减少和刺激释放有关。
DOI：
10.1046/j.1365-201x.1996.451171000.x
发表时间：
1996
期刊：
Acta physiologica Scandinavica
影响因子：
--
作者：
Mohammed Amrani;A. T. Goodwin;C. Gray;Magdi H. Yacoub
通讯作者：
Magdi H. Yacoub