Sinus-like dilatations of the mammary milk ducts, Ki67 expression, and CD3-positive T lymphocyte infiltration, in the mammary gland of wild European rabbits during pregnancy and lactation.
Sinus-like dilatations of the mammary milk ducts, Ki67 expression, and CD3-positive T lymphocyte infiltration, in the mammary gland of wild European rabbits during pregnancy and lactation.
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DOI：
10.1111/joa.12824
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发表时间：
2018-08
影响因子：
2.4
通讯作者：
Watson CJ
中科院分区：
文献类型：
--
作者：
Hughes K;Watson CJ
在怀孕和哺乳期的野生欧洲兔的乳腺中，可以辨认出乳腺管的窦状扩张。这些扩张表现为双层上皮衬里，腔上皮细胞表达基底和侧方E-钙粘附素。腔内层偶见双核乳腺上皮细胞。腔上皮细胞下面是细胞角蛋白14阳性细胞的基底层，由一层薄薄的纤维组织支撑。如Ki67表达所示，腔上皮细胞有明显的多节段增殖，提示在妊娠和哺乳期有分裂的能力。CD3阳性的T淋巴细胞既存在于上皮内，提示胞吐作用，也存在于导管上皮下的病灶中。我们认为，乳腺导管的窦状扩张可能会导致乳腺肿瘤的一种亚型，归类为导管起源。这些窦状扩张中的乳汁积累很可能为兔乳房炎病例中的细菌复制提供了一个利基环境。这些结构是乳腺天然免疫系统的重要组成部分，既是一种物理屏障，也是乳汁和乳腺免疫细胞之间的接口。
Sinus‐like dilatations of the mammary duct are recognisable in the mammary gland of pregnant and lactating wild European rabbits. These dilatations exhibit a bilaminar epithelial lining, with luminal epithelial cells expressing basal and lateral E‐cadherin. Occasional binucleated mammary epithelial cells are present in the luminal layer. Underlying the luminal epithelial cells is a basal layer of cytokeratin 14‐positive cells, supported by a thin layer of fibrous tissue. Multi‐segmental epithelial proliferation, as indicated by Ki67 expression, is apparent in the luminal epithelial cells, suggesting a capacity for division during pregnancy and lactation. CD3‐positive T lymphocytes are present both intraepithelially, suggesting exocytosis, and in foci subjacent to the ductular epithelium. We consider that sinus‐like dilatations of the mammary duct may have the potential to give rise to a subset of the mammary gland neoplasms classified as ductal in origin. Milk accumulation in these sinus‐like dilatations is likely to provide a niche for bacterial replication in cases of mastitis in rabbits. These structures are an important component of the innate immune system of the mammary gland, both as a physical barrier and as an interface between the milk and mammary immune cells.
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DOI：
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发表时间：
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期刊：
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DOI：
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发表时间：
2017-06-19
期刊：
Animals : an open access journal from MDPI
影响因子：
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通讯作者：
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