Racial differences between African-American and white women in insulin resistance and visceral adiposity are associated with differences in apoCIII containing apoAI and apoB lipoproteins.
Racial differences between African-American and white women in insulin resistance and visceral adiposity are associated with differences in apoCIII containing apoAI and apoB lipoproteins.
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DOI：
10.1186/1743-7075-11-56
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发表时间：
2014
影响因子：
4.5
通讯作者：
Sumner AE
中科院分区：
文献类型：
--
作者：
Wang L;Sacks FM;Furtado JD;Ricks M;Courville AB;Sumner AE
与白人相比，非洲裔美国人具有更高的HDL，更少的内脏脂肪组织（VAT）和更低的甘油三酯（TG）和apoCIII浓度，尽管他们具有更高的胰岛素抵抗。我们在非裔美国人和白色女性中研究了胰岛素抵抗和VAT对两种HDL亚型的apoAI浓度的影响，一种含有与冠心病（CHD）风险增加相关的apoCIII，另一种没有与CHD风险降低相关的apoCIII;以及对HDL和apoB脂蛋白的apoCIII浓度的影响。参与者是32名年龄相似的女性（39 ± 12岁对42 ± 11岁）（14名非洲裔美国人，18名白色）。非裔美国人的平均BMI为34 kg/m2，而白人为30。提供标准饮食（33%脂肪、52%碳水化合物、15%蛋白质）7天，然后在第8天提供试验餐（40%脂肪、40%碳水化合物、20%蛋白质）。根据最小模型计算胰岛素敏感性指数（SI）。在控制SI后，与白人相比，非裔美国人在apoCIII的HDL中具有更高的平均apoAI水平（分别为12.9 ± 2.8和10.9 ± 2.9 mg/dL，P = 0.05）。SI与apoCIII HDL中较高的apoAI相关，而VAT与此HDL亚类无关。apoB脂蛋白中apoCIII浓度的结果与此相反。调整SI后，非裔美国人的apoB脂蛋白中apoCIII较低。SI与总apoB脂蛋白中较低的apoCIII相关，而VAT与所有apoB脂蛋白中较高的apoCIII相关。对VAT的额外调整倾向于减少组间apoCIII的差异。当控制胰岛素敏感性时，非裔美国妇女的HDL和apoCIII水平高于白人。非裔美国人的胰岛素敏感性较低。胰岛素敏感性与HDL和apoCIII水平升高相关。非裔美国女性VLDL中的ApoCIII水平低于白人，也受胰岛素敏感性的影响，胰岛素敏感性与VLDL中的低apoCIII相关。VAT与apoB脂蛋白中的apoCIII有很强的相关性，但与apoCIII的HDL中的apoAI无相关性。ClinicalTrials.gov
African-Americans have higher HDL, less visceral adipose tissue (VAT) and lower triglyceride (TG) and apoCIII concentrations than whites, despite being more insulin-resistant. We studied in African-American and white women the influences of insulin resistance and VAT on the apoAI concentrations of two HDL subspecies, one that contains apoCIII that is associated with increased risk of coronary heart disease (CHD) and one that does not have apoCIII that is associated with decreased CHD; and on the apoCIII concentrations of HDL and of the apoB lipoproteins. The participants were 32 women (14 African-Americans, 18 white) of similar age (39 ± 12 vs. 42 ± 11y). Mean BMI was 34 kg/m2 in the African-Americans compared to 30 in the whites. A standard diet (33% fat, 52% carbohydrate, 15% protein) was provided for 7 days followed by a test meal (40% fat, 40% carbohydrate, 20% protein) on Day 8. Insulin sensitivity index (SI) was calculated from the minimal model. After controlling for SI, African-Americans have a higher mean apoAI level in HDL with apoCIII compared with whites (12.9 ± 2.8 and 10.9 ± 2.9 mg/dL, respectively, P = 0.05). SI was associated with higher apoAI in HDL with apoCIII, whereas VAT was not associated with this HDL subspecies. This pattern of results was reversed for apoCIII concentrations in apoB lipoproteins. After adjusting for SI, African-Americans had lower apoCIII in apoB lipoproteins. SI was associated with lower apoCIII in total apoB lipoproteins, whereas VAT was associated with higher apoCIII in all the apoB lipoproteins. Additional adjustment for VAT tended to reduce the difference in apoCIII between the groups. African-American women have a higher HDL with apoCIII level than whites when controlled for insulin sensitivity. African-Americans have lower insulin sensitivity. Insulin sensitivity is associated with higher levels of HDL with apoCIII. ApoCIII levels in VLDL are lower in African-American women than whites, also affected by insulin sensitivity which is associated with low apoCIII in VLDL. VAT has a strong association with apoCIII in apoB lipoproteins but not with apoAI in HDL with apoCIII. ClinicalTrials.gov Identifier: NCT00484861
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影响因子：
5.3
作者：
Sumner, Anne E.;Cowie, Catherine C.
通讯作者：
Cowie, Catherine C.
影响因子：
5.3
作者：
CHIVOT, L;MAINARD, F;FRUCHART, JC
通讯作者：
FRUCHART, JC
DOI：
10.1038/oby.2010.59
发表时间：
2010-11
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Preis SR;Massaro JM;Robins SJ;Hoffmann U;Vasan RS;Irlbeck T;Meigs JB;Sutherland P;D'Agostino RB Sr;O'Donnell CJ;Fox CS
通讯作者：
Fox CS
影响因子：
13.5
作者：
Guerrero, Richard;Vega, Gloria L.;Grundy, Scott M.;Browning, Jeffrey D.
通讯作者：
Browning, Jeffrey D.
影响因子：
5.8
作者：
Chow, Carson C.;Periwal, Vipul;Sumner, Anne E.
通讯作者：
Sumner, Anne E.