Understanding fibromyalgia: lessons from the broader pain research community.
Understanding fibromyalgia: lessons from the broader pain research community.
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DOI：
10.1016/j.jpain.2009.06.001
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Clauw DJ
中科院分区：
文献类型：
--
作者：
Williams DA;Clauw DJ
纤维肌痛（FM）是一种慢性疼痛症状，其特征是中央介导的疼痛和感觉过程的增强。怀疑标志着这种疾病的历史，但最近的研究已经确定了支持与这种疾病相关的许多症状的神经生物学基础。早期的FM研究在风湿病学界具有前所未有的自由度，大量借鉴了慢性疼痛研究中应用的理论和方法。这些见解促进了FM研究的快速发展；其中最重要的是放弃了外围焦点，转而研究与中枢增强相关的中枢机制。目前，在FM遗传学、患者评估、新的治疗靶点和新的治疗方法方面正在快速发现。这种见解不太可能只局限于FM的应用；但也可能与更广泛的疼痛研究领域有关。本文回顾了FM的历史及其诊断，支持FM疼痛中枢增强的证据，中枢增强的潜在机制，FM综合护理的当前方法，以及FM研究与其他慢性疼痛疾病之间的积极合作领域。
Fibromaylgia (FM) is a chronic pain condition marked by centrally-mediated augmentation of pain and sensory processes. Skepticism has marked the history of this condition, but more recent study has identified neurobiological underpinnings supporting many of the symptoms associated with this condition. Early research in FM had unprecedented latitude within the Rheumatology community to borrow heavily from theory and methods being applied in chronic pain research more generally. These insights facilitated rapid advances in FM research; not the least of which was the abandonment of a peripheral focus in favor of studying central mechanisms associated with central augmentation. Currently, rapid paced discovery is taking place in FM genetics, patient assessment, new therapeutic targets, and novel methods of treatment delivery. Such insights are not likely to be limited in application just to FM; but could have relevance to the broader field of pain research as well. This manuscript reviews the history of FM and its diagnosis, evidence supporting central augmentation of pain in FM, potential mechanisms of central augmentation, current approaches to integrated care of FM, and areas of active collaboration between FM research and other chronic pain conditions.
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影响因子：
1.1
作者：
Adigüzel, O;Kaptanoglu, E;Nacitarhan, V
通讯作者：
Nacitarhan, V
影响因子：
22.8
作者：
ALFICI, S;SIGAL, M;LANDAU, M
通讯作者：
LANDAU, M
DOI：
10.1053/eujp.1999.0148
发表时间：
2000-01-01
期刊：
EUROPEAN JOURNAL OF PAIN-LONDON
影响因子：
--
作者：
Anderberg, UM;Marteinsdottir, I;von Knorring, L
通讯作者：
von Knorring, L
DOI：
10.1093/geronj/46.6.p352
发表时间：
1991-11-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
BLUMENTHAL, JA;EMERY, CF;COLEMAN, RE
通讯作者：
COLEMAN, RE
影响因子：
3
作者：
BURTON, AK;TILLOTSON, KM;HOLLIS, S
通讯作者：
HOLLIS, S