Something old, something new: the origins of an unusual renal cell underpinning a beetle water-conserving mechanism
Something old, something new: the origins of an unusual renal cell underpinning a beetle water-conserving mechanism
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旧事与新事：支撑甲虫节水机制的不寻常肾细胞的起源
DOI：
10.1101/2024.03.01.582930
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Beaven R
中科院分区：
文献类型：
--
作者：
Beaven R
在独特的渗透调节适应能力的支持下，天牛在缺水环境中的定居非常成功。这包括他们器官的隐肾排列，其中他们的肾/马氏管的一部分被绑在直肠表面。在隐肾小管内，一种不寻常的细胞类型--纤毛膜，对维持水源的保存起着关键的生理作用。关于这些不寻常的肾细胞的发育机制或进化，人们一无所知。在这里，我们研究了支撑卡氏拟谷盗体内纤毛虫发育的机制。我们发现，尽管果蝇缺乏一个隐核排列，但它表达并需要顶端转录因子，类似于果蝇的次级肾细胞，表达Teashirt和Ttop。另一种转录因子Dachshund被用来确定纤毛虫的特征，并将它们与Tribolium肾小管非隐肾区的次级细胞区分开来。腊肠在果蝇的次级细胞亚群中也有表达。甲虫谱系特有的纤毛虫，似乎起源于祖先存在的一种特定的肾脏细胞类型，并由保守的转录因子库指定。
Tenebrionid beetles have been highly successful in colonising environments where water is scarce, underpinned by their unique osmoregulatory adaptations. These include a cryptonephridial arrangement of their organs, in which part of their renal/Malpighian tubules are bound to the surface of the rectum. Within the cryptonephridial tubules, an unusual cell type, the leptophragmata, plays a key physiological role underpinning water conservation. Nothing was known about the developmental mechanisms or evolution of these unusual renal cells. Here, we investigate mechanisms underpinning leptophragmata development in Tribolium castaneum. We find that leptophragmata express and require the Tiptop transcription factor, similar to secondary renal cells in Drosophila melanogaster, which express Teashirt and Tiptop, despite Drosophila lacking a crypronephridial arrangement. An additional transcription factor, Dachshund, is required to establish leptophragmata identity and to distinguish them from the secondary cells in the non-cryptonephridial region of renal tubule of Tribolium. Dachshund is also expressed in a sub-population of secondary cells in Drosophila. Leptophragmata, which are unique to the beetle lineage, appear to have originated from a specific renal cell type present ancestrally and to be specified by a conserved repertoire of transcription factors.
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DOI：
10.1242/dev.088989
发表时间：
2013-03
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Denholm B;Hu N;Fauquier T;Caubit X;Fasano L;Skaer H
通讯作者：
Skaer H
影响因子：
9.2
作者：
Robin Beaven;K. V. Halberg;B. Denholm
通讯作者：
B. Denholm
DOI：
--
发表时间：
1975
期刊：
影响因子：
--
作者：
B. Dunbar;P. Winston
通讯作者：
P. Winston
粉虫（黄粉虫：鞘翅目）的蒸发和大气湿度。
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
P. A. Buxton
通讯作者：
P. A. Buxton
影响因子：
10.5
作者：
Bessa, J;Gebelein, B;Mann, RS
通讯作者：
Mann, RS