Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of Hepatocellular Carcinoma.
Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of Hepatocellular Carcinoma.
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DOI：
10.3390/ijms160614086
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发表时间：
2015-06-19
影响因子：
5.6
通讯作者：
Nishiguchi S
中科院分区：
文献类型：
--
作者：
Enomoto H;Nakamura H;Liu W;Nishiguchi S
肝细胞癌（HCC）的发生是丙型肝炎病毒感染引起的重要并发症，我们的主要研究主题是鉴定一种与HCC进展相关的新的生长因子。HDGF（hepatoma-derived growth factor）是一种新的生长因子，属于一个新的基因家族。HDGF最初从肝癌细胞系的条件培养基中纯化。HDGF作为DNA结合核因子和分泌蛋白通过受体介导的途径起作用，促进细胞增殖。HDGF是一种独特的多功能蛋白质，可作为生长因子、血管生成因子和抗凋亡因子发挥作用，参与多种恶性疾病的发生和发展。HDGF的表达水平可能是预测包括HCC在内的各种恶性肿瘤患者无病生存期和总生存期的独立预后因素。此外，HDGF的过表达促进HCC细胞的增殖，而HDGF表达的降低抑制HCC细胞的增殖。本文概述了HDGF的特性，并描述了HDGF作为肝癌生长促进因子的潜在作用。
The development of hepatocellular carcinoma (HCC) is an important complication of viral infection induced by hepatitis virus C, and our major research theme is to identify a new growth factor related to the progression of HCC. HDGF (hepatoma-derived growth factor) is a novel growth factor that belongs to a new gene family. HDGF was initially purified from the conditioned medium of a hepatoma cell line. HDGF promotes cellular proliferation as a DNA binding nuclear factor and a secreted protein acting via a receptor-mediated pathway. HDGF is a unique multi-functional protein that can function as a growth factor, angiogenic factor and anti-apoptotic factor and it participates in the development and progression of various malignant diseases. The expression level of HDGF may be an independent prognostic factor for predicting the disease-free and overall survival in patients with various malignancies, including HCC. Furthermore, the overexpression of HDGF promotes the proliferation of HCC cells, while a reduction in the HDGF expression inhibits the proliferation of HCC cells. This article provides an overview of the characteristics of HDGF and describes the potential role of HDGF as a growth-promoting factor for HCC.
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