Vaccine Hesitancy and Rejection of a Vaccine for the Novel Coronavirus in the United States.
Vaccine Hesitancy and Rejection of a Vaccine for the Novel Coronavirus in the United States.
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疫苗犹豫不决和对美国新型冠状病毒的疫苗排斥。
DOI：
10.3389/fimmu.2021.558270
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发表时间：
2021
影响因子：
7.3
通讯作者：
Zikmund-Fisher BJ
中科院分区：
文献类型：
--
作者：
Shih SF;Wagner AL;Masters NB;Prosser LA;Lu Y;Zikmund-Fisher BJ
随着COVID-19疫苗的问世，有关疫苗犹豫的讨论越来越多。然而，目前尚不清楚一般疫苗犹豫和COVID-19疫苗排斥之间是否存在共同的模式，或者这是两个不同的概念。本研究描述了一种假设的COVID-19疫苗的排斥反应，并比较了一般疫苗犹豫与COVID-19疫苗排斥反应之间的关联模式。该调查于2020年3月20日至22日在网上进行。与会者回答了关于疫苗犹豫的问题，并回答了在不同的安全性和有效性概况下他们是否会接受疫苗。我们通过logistic回归评估了COVID-19排斥反应和一般疫苗犹豫的差异。在713名参与者中，33.0%的人对疫苗犹豫不决，18.4%的人会拒绝接种COVID-19疫苗。接受度因有效性概况而异：10.2%的人会拒绝95%有效的COVID-19疫苗，但32.4%的人会拒绝50%有效的疫苗。疫苗犹豫者拒绝接种COVID-19疫苗的可能性显著增加[优势比（OR）： 5.56, 95%可信区间（CI）： 3.39, 9.11]。在多变量logistic回归模型中，性别、种族/民族、家庭收入和政治派别在疫苗犹豫和COVID-19疫苗排斥方面存在相似的模式。但是，城市化（P=0.0146，农村居民不太可能成为COVID-19疫苗拒绝者，但总体上更有可能对疫苗犹豫不决）和年龄（P=0.0037， COVID-19疫苗拒绝的年龄差异较小，但总体上在年轻人群中存在更强的疫苗犹豫梯度）的相关性方向发生了逆转。在COVID-19流行的早期阶段，疫苗犹豫和COVID-19疫苗排斥的模式相对相似。相当多的少数人会拒绝COVID-19疫苗，尤其是效果不太理想的疫苗。引入COVID-19疫苗的准备工作应预见到大量犹豫并针对担忧，特别是在年轻人中。
The arrival of the COVID-19 vaccine has been accompanied by increased discussion of vaccine hesitancy. However, it is unclear if there are shared patterns between general vaccine hesitancy and COVID-19 vaccine rejection, or if these are two different concepts. This study characterized rejection of a hypothetical COVID-19 vaccine, and compared patterns of association between general vaccine hesitancy and COVID-19 vaccine rejection. The survey was conducted online March 20-22, 2020. Participants answered questions on vaccine hesitancy and responded if they would accept the vaccine given different safety and effectiveness profiles. We assessed differences in COVID-19 rejection and general vaccine hesitancy through logistic regressions. Among 713 participants, 33.0% were vaccine hesitant, and 18.4% would reject a COVID-19 vaccine. Acceptance varied by effectiveness profile: 10.2% would reject a 95% effective COVID-19 vaccine, but 32.4% would reject a 50% effective vaccine. Those vaccine hesitant were significantly more likely to reject COVID-19 vaccination [odds ratio (OR): 5.56, 95% confidence interval (CI): 3.39, 9.11]. In multivariable logistic regression models, there were similar patterns for vaccine hesitancy and COVID-19 vaccine rejection by gender, race/ethnicity, family income, and political affiliation. But the direction of association flipped by urbanicity (P=0.0146, with rural dwellers less likely to be COVID-19 vaccine rejecters but more likely to be vaccine hesitant in general), and age (P=0.0037, with fewer pronounced differences across age for COVID-19 vaccine rejection, but a gradient of stronger vaccine hesitancy in general among younger ages). During the COVID-19 epidemic’s early phase, patterns of vaccine hesitancy and COVID-19 vaccine rejection were relatively similar. A significant minority would reject a COVID-19 vaccine, especially one with less-than-ideal effectiveness. Preparations for introducing the COVID-19 vaccine should anticipate substantial hesitation and target concerns, especially among younger adults.
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影响因子：
2.4
作者：
Wagner AL;Boulton ML;Sun X;Mukherjee B;Huang Z;Harmsen IA;Ren J;Zikmund-Fisher BJ
通讯作者：
Zikmund-Fisher BJ
影响因子：
5.5
作者：
Bryden, Gabrielle M.;Browne, Matthew;Unsworth, Carolyn
通讯作者：
Unsworth, Carolyn
影响因子：
5.4
作者：
Streefland, P;Chowdhury, AMR;Ramos-Jimenez, P
通讯作者：
Ramos-Jimenez, P
影响因子：
5.5
作者：
Larson, Heidi J.;Jarrett, Caitlin;Wilson, Rose
通讯作者：
Wilson, Rose
影响因子：
19
作者：
Peretti-Watel, P.;Verger, P.;Beck, F.
通讯作者：
Beck, F.