Advances in Lung Cancer Driver Genes Associated With Brain Metastasis.
Advances in Lung Cancer Driver Genes Associated With Brain Metastasis.
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与脑转移相关的肺癌驱动基因的进展。
DOI：
10.3389/fonc.2020.606300
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发表时间：
2020
影响因子：
4.7
通讯作者：
Yuan X
中科院分区：
文献类型：
--
作者：
Kang Y;Jin Y;Li Q;Yuan X
脑转移是肺癌的常见并发症之一，尽管治疗策略取得了进展，但脑转移仍是晚期癌症患者死亡的重要原因。具有阳性驱动基因的肺癌具有较高的脑转移发生率和风险，这表明与这些基因相关的驱动事件可能是检测和预防疾病进展的生物标志物。常见的肺癌驱动基因主要编码受体酪氨酸激酶（RTK），其是与外部信号相互作用的重要内部信号分子。RTK及其下游信号通路对于肿瘤细胞在脑中的存活、侵袭和定殖至关重要。此外，新的肿瘤驱动基因也被发现与肺癌脑转移密切相关，这些基因也编码与RTK信号通路密切相关的重要分子。本文就肺癌驱动基因与脑转移的关系进行综述，并对驱动基因相关通路在脑转移中的作用机制进行总结。通过了解脑转移的分子特征，可以更好地对肺癌患者进行分层，并对脑转移高危人群进行预警，有助于促进肺癌的个体化治疗。
Brain metastasis, one of the common complications of lung cancer, is an important cause of death in patients with advanced cancer, despite progress in treatment strategies. Lung cancers with positive driver genes have higher incidence and risk of brain metastases, suggesting that driver events associated with these genes might be biomarkers to detect and prevent disease progression. Common lung cancer driver genes mainly encode receptor tyrosine kinases (RTKs), which are important internal signal molecules that interact with external signals. RTKs and their downstream signal pathways are crucial for tumor cell survival, invasion, and colonization in the brain. In addition, new tumor driver genes, which also encode important molecules closely related to the RTK signaling pathway, have been found to be closely related to the brain metastases of lung cancer. In this article, we reviewed the relationship between lung cancer driver genes and brain metastasis, and summarized the mechanism of driver gene-associated pathways in brain metastasis. By understanding the molecular characteristics during brain metastasis, we can better stratify lung cancer patients and alert those at high risk of brain metastasis, which helps to promote individual therapy for lung cancer.
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染色体不稳定性通过胞质DNA反应驱动转移。
影响因子：
64.8
作者：
Bakhoum SF;Ngo B;Laughney AM;Cavallo JA;Murphy CJ;Ly P;Shah P;Sriram RK;Watkins TBK;Taunk NK;Duran M;Pauli C;Shaw C;Chadalavada K;Rajasekhar VK;Genovese G;Venkatesan S;Birkbak NJ;McGranahan N;Lundquist M;LaPlant Q;Healey JH;Elemento O;Chung CH;Lee NY;Imielenski M;Nanjangud G;Pe'er D;Cleveland DW;Powell SN;Lammerding J;Swanton C;Cantley LC
通讯作者：
Cantley LC
遗传对人体组织基因表达的影响。
影响因子：
64.8
作者：
GTEx Consortium;Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group;Statistical Methods groups—Analysis Working Group;Enhancing GTEx (eGTEx) groups;NIH Common Fund;NIH/NCI;NIH/NHGRI;NIH/NIMH;NIH/NIDA;Biospecimen Collection Source Site—NDRI;Biospecimen Collection Source Site—RPCI;Biospecimen Core Resource—VARI;Brain Bank Repository—University of Miami Brain Endowment Bank;Leidos Biomedical—Project Management;ELSI Study;Genome Browser Data Integration &Visualization—EBI;Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz;Lead analysts:;Laboratory, Data Analysis &Coordinating Center (LDACC):;NIH program management:;Biospecimen collection:;Pathology:;eQTL manuscript working group:;Battle A;Brown CD;Engelhardt BE;Montgomery SB
通讯作者：
Montgomery SB
影响因子：
16.6
作者：
Caetano MS;Hassane M;Van HT;Bugarin E;Cumpian AM;McDowell CL;Cavazos CG;Zhang H;Deng S;Diao L;Wang J;Evans SE;Behrens C;Wistuba II;Fuqua SAW;Lin H;Stabile LP;Watowich SS;Kadara H;Moghaddam SJ
通讯作者：
Moghaddam SJ
影响因子：
30.8
作者：
Blakely CM;Watkins TBK;Wu W;Gini B;Chabon JJ;McCoach CE;McGranahan N;Wilson GA;Birkbak NJ;Olivas VR;Rotow J;Maynard A;Wang V;Gubens MA;Banks KC;Lanman RB;Caulin AF;St John J;Cordero AR;Giannikopoulos P;Simmons AD;Mack PC;Gandara DR;Husain H;Doebele RC;Riess JW;Diehn M;Swanton C;Bivona TG
通讯作者：
Bivona TG
DOI：
10.1126/science.1253462
发表时间：
2014-10-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
de Bruin EC;McGranahan N;Mitter R;Salm M;Wedge DC;Yates L;Jamal-Hanjani M;Shafi S;Murugaesu N;Rowan AJ;Grönroos E;Muhammad MA;Horswell S;Gerlinger M;Varela I;Jones D;Marshall J;Voet T;Van Loo P;Rassl DM;Rintoul RC;Janes SM;Lee SM;Forster M;Ahmad T;Lawrence D;Falzon M;Capitanio A;Harkins TT;Lee CC;Tom W;Teefe E;Chen SC;Begum S;Rabinowitz A;Phillimore B;Spencer-Dene B;Stamp G;Szallasi Z;Matthews N;Stewart A;Campbell P;Swanton C
通讯作者：
Swanton C