Serum lnc34a is a potential prediction biomarker for bone metastasis in hepatocellular carcinoma patients.
Serum lnc34a is a potential prediction biomarker for bone metastasis in hepatocellular carcinoma patients.
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血清lnc34a是肝细胞癌患者骨转移的潜在预测生物标志物
DOI：
10.1186/s12885-021-07808-6
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发表时间：
2021-02-15
期刊：
影响因子：
3.8
通讯作者：
Xiang ZL
中科院分区：
文献类型：
--
作者：
Zhang L;Niu H;Yang P;Ma J;Yuan BY;Zeng ZC;Xiang ZL
背景早期筛查和干预治疗是改善肝癌骨转移患者预后的关键。方法采用实时荧光定量聚合酶链反应（real-time polymerase chain reaction，PCR）技术检测157例HCC患者血清中lnc 34 a的表达水平，并分析其与HCC骨转移的关系。单因素分析和多因素分析进行，以确定统计学显着variables. Resultslnc 34 a的表达水平，从肝癌患者骨转移的血清中显着高于那些没有骨转移。分析表明lnc 34 a高表达、血管浸润和巴塞罗那临床肝癌（BCLC）分期与骨转移有关。此外，lnc 34 a的表达是专门与骨转移，而不是肺或淋巴结转移HCC.ConclusionsHigh血清lnc 34 a的表达是一个独立的危险因素，发展成骨转移的HCC。
BackgroundEarly screening and intervention therapies are crucial to improve the prognosis of hepatocellular carcinoma (HCC) patients with bone metastasis. We aimed to identify serum lncRNA as a prediction biomarker in HCC bone metastasis.MethodsThe expression levels of lnc34a in serum samples from 157 HCC patients were detected by quantitative real-time polymerase chain reaction (PCR). Univariate analysis and multivariate analysis were performed to determine statistically significant variables.ResultsExpression levels of lnc34a in serum from HCC patients with bone metastasis were significantly higher than those without bone metastasis. The high expressions of lnc34a, vascular invasion and Barcelona Clinic Liver Cancer (BCLC) stage were associated with bone metastasis by analysis. Moreover, lnc34a expression was specifically associated with bone metastasis rather than lung or lymph node metastasis in HCC.ConclusionsHigh serum lnc34a expression was a independent risk factor for developing bone metastasis in HCC.
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