Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT).
Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT).
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DOI：
10.1186/1745-6215-14-152
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发表时间：
2013-05-27
期刊：
影响因子：
2.5
通讯作者：
Whitaker R
中科院分区：
文献类型：
--
作者：
Clare L;Bayer A;Burns A;Corbett A;Jones R;Knapp M;Kopelman M;Kudlicka A;Leroi I;Oyebode J;Pool J;Woods B;Whitaker R
初步证据表明，以目标为导向的认知康复（CR）可能是早期阿尔茨海默病，血管性或混合性痴呆患者及其护理人员的临床有效干预措施。本研究旨在确定CR是否是早期痴呆症患者及其护理人员的临床有效和具有成本效益的干预措施。在这项多中心、单盲、随机对照试验中，480名早期痴呆患者将随机接受常规治疗或认知康复治疗（3个月内10次治疗，6个月内4次维持治疗）。我们将比较认知康复与常规治疗在以下方面的有效性：在被确定为引起早期痴呆症患者关注的领域改善自我报告和护理人员评定的目标表现;改善早期痴呆症患者的生活质量，自我效能，情绪和认知;以及降低压力水平并改善早期痴呆症患者的护理人员的生活质量。与常规治疗相比，目标导向的认知康复的增量成本效益也将被检查。如果这项研究证实了认知康复的益处和成本效益，那么研究如何将以目标为导向的认知康复方法最有效地整合到日常医疗保健服务中将非常重要。我们的目标是提供培训和编写材料，以支持在试验结束后实施这一方法。当前对照试验ISRCTN 21027481
Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically effective intervention for people with early-stage Alzheimer’s disease, vascular or mixed dementia and their carers. This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers. In this multi-centre, single-blind randomised controlled trial, 480 people with early-stage dementia, each with a carer, will be randomised to receive either treatment as usual or cognitive rehabilitation (10 therapy sessions over 3 months, followed by 4 maintenance sessions over 6 months). We will compare the effectiveness of cognitive rehabilitation with that of treatment as usual with regard to improving self-reported and carer-rated goal performance in areas identified as causing concern by people with early-stage dementia; improving quality of life, self-efficacy, mood and cognition of people with early-stage dementia; and reducing stress levels and ameliorating quality of life for carers of participants with early-stage dementia. The incremental cost-effectiveness of goal-oriented cognitive rehabilitation compared to treatment as usual will also be examined. If the study confirms the benefits and cost-effectiveness of cognitive rehabilitation, it will be important to examine how the goal-oriented cognitive rehabilitation approach can most effectively be integrated into routine health-care provision. Our aim is to provide training and develop materials to support the implementation of this approach following trial completion. Current Controlled Trials ISRCTN21027481
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影响因子：
2.4
作者：
Clare, L;Wilson, BA;Hodges, JR
通讯作者：
Hodges, JR
影响因子：
3.3
作者：
Brooks, R
通讯作者：
Brooks, R
影响因子：
3.4
作者：
Clare, L;Wilson, BA;Hodges, JR
通讯作者：
Hodges, JR
影响因子：
4.2
作者：
Bandura, A
通讯作者：
Bandura, A
影响因子：
7.2
作者：
Clare, Linda;Linden, David E. J.;Rugg, Michael D.
通讯作者：
Rugg, Michael D.