Olfactory jump reflex habituation in Drosophila and effects of classical conditioning mutations.

Olfactory jump reflex habituation in Drosophila and effects of classical conditioning mutations.
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DOI:
10.1080/01677060701247508
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发表时间:
2007-01
影响因子:
1.9
通讯作者:
Tully T
Tully T
中科院分区:
医学4区
文献类型:
--
作者:
Asztalos Z;Arora N;Tully T

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习惯化是一种非联想学习机制,其中对重复刺激的初始反应逐渐减弱。这是最简单和最普遍的行为可塑性形式之一。到目前为止,无论是潜在的分子机制还是精确的习惯化神经网络都没有得到很好的理解。我们已经开发了一种新的范式来量化果蝇嗅觉跳跃反射的习惯化。我们目前的数据表明这种现象的几个行为特性,通常在其他物种中观察到。我们还表明,傻瓜和芜菁甘蓝记忆突变体的行为异常,在此试验中,这表明该试验可能会被用于行为筛选新的突变体的缺陷,在这种简单的形式的行为可塑性。
Habituation is a nonassociative learning mechanism, in which an initial response toward repeated stimuli gradually wanes. This is amongst the simplest and most widespread forms of behavioral plasticity. So far, neither the underlying molecular mechanisms nor the precise neural networks of habituation are well understood. We have developed a novel paradigm to quantify habituation of the olfactory jump reflex in Drosophila. We present data demonstrating several behavioral properties of this phenomenon, generally observed in other species. We also show that the dunce and rutabaga memory mutants behave abnormally in this assay, suggesting that this assay might be used in behavioral screens for new mutants with defects in this simpler form of behavioral plasticity.
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发表时间: 1970-01-01
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