Cognitive decline and brain amyloid-β accumulation across 3 years in adults with Down syndrome.
Cognitive decline and brain amyloid-β accumulation across 3 years in adults with Down syndrome.
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DOI：
10.1016/j.neurobiolaging.2017.05.019
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发表时间：
2017-10
影响因子：
4.2
通讯作者：
Christian BT
中科院分区：
文献类型：
--
作者：
Hartley SL;Handen BL;Devenny D;Mihaila I;Hardison R;Lao PJ;Klunk WE;Bulova P;Johnson SC;Christian BT
患有唐氏综合征（DS）的成人具有阿尔茨海默病（AD）的高发病率，这为探索AD神经病理学的早期临床前阶段提供了独特的机会。我们通过PET示踪剂[11 C]匹兹堡化合物B（PiB）在间隔3年的两个数据收集周期中检查了脑淀粉样蛋白-β蓄积的变化，并在58例无临床AD的DS成人中检查了认知功能的下降。扣带回前部、楔前叶皮质、顶叶皮质和前腹侧纹状体的PiB保留增加。在两个周期中，14名（27.5%）参与者始终为PiB+，31名（60.8%）始终为PiB−，6名（11.7%）从周期1的PiB−转换为周期2的PiB+。整体淀粉样蛋白-β增加与言语情景记忆、视觉情景记忆、执行功能和精细运动处理速度下降相关。持续PiB+的参与者表现出情景记忆的恶化，而持续PiB-的参与者表现出稳定或改善的表现。β淀粉样蛋白蓄积可能是DS临床前AD认知功能下降的促成因素或生物标志物。
Adults with Down syndrome (DS) have a high incidence of Alzheimer’s disease (AD), providing a unique opportunity to explore the early, preclinical stages of AD neuropathology. We examined change in brain amyloid-β accumulation via the PET tracer [11C] Pittsburgh compound B (PiB) across two data collection cycles, spaced 3 years apart, and decline in cognitive functioning in 58 adults with DS without clinical AD. PiB retention increased in the anterior cingulate gyrus, precuneus cortex, parietal cortex and anterior ventral striatum. Across the two cycles, 14 (27.5%) participants were consistently PiB+, 31 (60.8%) were consistently PiB−, and 6 (11.7%) converted from PiB− at Cycle 1 to PiB+ at Cycle 2. Increased global amyloid-β was related to decline in verbal episodic memory, visual episodic memory, executive functioning, and fine motor processing speed. Participants who were consistently PiB+ demonstrated worsening of episodic memory, whereas participants who were consistently PiB− evidenced stable or improved performance. Amyloid-β accumulation may be a contributor to or biomarker of declining cognitive functioning in preclinical AD in DS.
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影响因子：
3.6
作者：
McCarron, M.;McCallion, P.;Mulryan, N.
通讯作者：
Mulryan, N.
影响因子：
19.9
作者：
Liljeholm M;O'Doherty JP
通讯作者：
O'Doherty JP
影响因子：
--
作者：
Aizenstein, Howard Jay;Nebes, Robert D.;Saxton, Judith A.;Price, Julie C.;Mathis, Chester A.;Tsopelas, Nicholas D.;Ziolko, Scott K.;James, Jeffrey A.;Snitz, Beth E.;Houck, Patricia R.;Bi, Wenzhu;Cohen, Ann D.;Lopresti, Brian J.;DeKosky, Steven T.;Halligan, Edythe M.;Klunk, William E.
通讯作者：
Klunk, William E.
影响因子：
14.5
作者：
Hartley, Sigan L.;Handen, Benjamin L.;Christian, Bradley T.
通讯作者：
Christian, Bradley T.
DOI：
10.1016/j.dadm.2017.05.001
发表时间：
2017-01-01
期刊：
Alzheimer's & dementia (Amsterdam, Netherlands)
影响因子：
--
作者：
Lao, Patrick J;Handen, Ben L;Christian, Bradley T
通讯作者：
Christian, Bradley T