Multiple system aging-related tau astrogliopathy with complex proteinopathy in an oligosymptomatic octogenarian.
Multiple system aging-related tau astrogliopathy with complex proteinopathy in an oligosymptomatic octogenarian.
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多个系统衰老相关的tau星形胶质细胞病，具有复杂的蛋白质病，在寡症状的八十岁室中。
DOI：
10.1111/neup.12708
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Kovacs GG
中科院分区：
文献类型：
--
作者：
Klotz S;Fischer P;Hinterberger M;Ricken G;Hönigschnabl S;Gelpi E;Kovacs GG
多种神经退行性蛋白病的组合越来越被认识到。它们共同会加重神经元功能障碍，并导致复杂的神经症状。我们报告一位八十多岁女性直肠癌多发性神经外转移的病例。她试图自杀，最终导致入院9 天后心肺衰竭。除了自杀未遂和迟发性抑郁症外，没有其他精神或神经症状的报道。出乎意料的是，组织病理学检查显示，所有五种类型(软膜下、室管膜下、灰质和白质以及血管周围)的老年相关tau星形胶质病(ARTAG)都影响到皮质和皮质下脑区。这种病理与中度阿尔茨海默病神经病理改变(A2B2C2评分)、脑淀粉样血管病变、路易体型α-突触核蛋白病(Braak4期)和一种同样累及星形胶质细胞的43 kDa多系统反式激活反应DNA结合蛋白病有关。综上所述，我们报告了一个复杂而广泛的多种蛋白病变的组合，在一名自杀未遂的患者中广泛存在五种类型的ARTAG。虽然没有进行纵向心理测量测试和神经心理学评估，但这份报告提出了认知阈值和病理负荷的问题，描述了ARTAG影响异常广泛的大脑区域，并支持复杂蛋白质病应被视为老年人的常见疾病的观点。
The combination of multiple neurodegenerative proteinopathies is increasingly recognized. Together they can potentiate neuronal dysfunction and contribute to complex neurological symptoms. We report an octogenarian female case of multiple extraneural metastases of a rectal carcinoma. She attempted suicide, which ultimately led to cardiorespiratory failure nine days after hospital admission. Apart from the suicide attempt and late‐onset depression, other psychiatric or neurological symptoms were not reported. Unexpectedly, histopathologic examination revealed prominent aging‐related tau astrogliopathy (ARTAG) of all five types (subpial, subependymal, grey and white matter, and perivascular) affecting cortical and subcortical brain regions. This pathology was associated with intermediate Alzheimer's disease neuropathologic change (A2B2C2 score), cerebral amyloid angiopathy, Lewy body‐type α‐synuclein proteinopathy (Braak stage 4), and a multiple system transactivation response DNA‐binding protein of 43 kDa (TDP‐43) proteinopathy also involving the astroglia. In summary, we report a complex and extensive combination of multiple proteinopathies with widespread ARTAG of all five types in a patient who had attempted suicide. Although longitudinal psychometric tests and neuropsychological evaluations were not performed, this report poses the question of thresholds of cognition and pathology load, describes ARTAG affecting unusually widespread brain regions, and supports the notion that complex proteinopathies should be regarded as a frequent condition in the elderly.
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影响因子：
7.1
作者：
Kovacs GG;Xie SX;Robinson JL;Lee EB;Smith DH;Schuck T;Lee VM;Trojanowski JQ
通讯作者：
Trojanowski JQ
影响因子：
2.8
作者：
Guo, Zhongwei;Liu, Xiaozheng;Chen, Wei
通讯作者：
Chen, Wei
影响因子：
2.4
作者：
Kovacs, Gabor G.;Alafuzoff, Irina;Budka, Herbert
通讯作者：
Budka, Herbert
影响因子：
12.7
作者：
Al-Sarraj, Safa;King, Andrew;Shaw, Christopher E.
通讯作者：
Shaw, Christopher E.
DOI：
10.1523/jneurosci.0490-10.2010
发表时间：
2010-05-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Clinton LK;Blurton-Jones M;Myczek K;Trojanowski JQ;LaFerla FM
通讯作者：
LaFerla FM