High-frequency ultrasound of the skin in systemic sclerosis: an exploratory study to examine correlation with disease activity and to define the minimally detectable difference.
High-frequency ultrasound of the skin in systemic sclerosis: an exploratory study to examine correlation with disease activity and to define the minimally detectable difference.
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DOI：
10.1186/s13075-018-1686-9
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发表时间：
2018-08-16
影响因子：
4.9
通讯作者：
Liu A
中科院分区：
文献类型：
--
作者：
Li H;Furst DE;Jin H;Sun C;Wang X;Yang L;He J;Wang Y;Liu A
皮肤增厚是系统性硬化症（SSc）患者的一个主要临床特征。我们使用高频超声（HFU）和改良Rodnan皮肤评分（mRSS）研究了SSc患者皮肤厚度的变化，以评估HFU在皮肤受累中应用的可行性以及HFU与临床特征之间的关系。在这项前瞻性横断面研究中，我们连续招募了 31 名 SSc 患者和 31 名年龄匹配、性别匹配的健康对照。使用 18 MHz 超声波探头测量五个不同皮肤部位的皮肤厚度。记录总皮肤厚度 (TST) 和使用分类 mRSS 评分的皮肤厚度，并与 HFU 进行比较。对欧洲硬皮病试验和研究（EUSTAR）组疾病活动指数（EUSTAR-DAI）和其他临床表现进行评估和分析。 SSc 患者的 TST 比健康对照者厚（P<0.001），与总 mRSS 和 EUSTAR-DAI 呈正相关，与疾病持续时间呈负相关（P<0.05）。 TST 较高的患者，EUSTAR-DAI、mRSS、C 反应蛋白 (CRP) 较高，肺一氧化碳弥散能力 (DLCO) 较低 (P < 0.05)。即使在接受临床评估的患者中，mRSS 也表明皮肤厚度正常。这对于 1 和 2 的局部 mRSS 也是如此 (P < 0.01)。受试者工作特征 (ROC) 曲线下面积为 0.831，在预测概率为 7.4 毫米作为获取皮肤厚度的最佳截止点时，灵敏度为 77.4%，特异性为 87.1%。在这项研究中，HFU 能够测量皮肤厚度，它与 SSc 活性的有效测量定量相关，并确定了最小的可检测差异。本文的在线版本 (10.1186/s13075-018-1686-9) 包含补充材料，可供授权用户使用。
Thickened skin is a major clinical feature in patients with systemic sclerosis (SSc). We investigated changes of skin thickness in patients with SSc using both high frequency ultrasound (HFU) and the modified Rodnan skin score (mRSS) to evaluate the feasibility of application of HFU in skin involvement and the relationship between HFU and clinical profiles. We recruited 31 consecutive patients with SSc and 31 age-matched and sex-matched healthy controls in this prospective, cross-sectional study. Skin thickness was measured by an 18-MHz ultrasonic probe at five different skin sites. Total skin thickness (TST) and skin thickness using categorical mRSS scores were recorded and compared to HFU. The European Scleroderma Trial and Research (EUSTAR) group Disease Activity Index (EUSTAR-DAI) and other clinical manifestations were assessed and analyzed. TST in patients with SSc was thicker than in healthy controls (P < 0.001), and correlated positively with total mRSS and the EUSTAR-DAI and correlated negatively with disease duration (P < 0.05). Patients with higher TST had higher EUSTAR-DAI, mRSS, C-reactive protein (CRP) and lower diffusing capacity of the lung for carbon monoxide (DLCO) (P < 0.05). Even in patients who on clinical assessment were assigned an mRSS that suggested the skin thickness was normal. This was also true to mRSS locally of 1 and 2 (P < 0.01). The area under the receiver operator characteristic (ROC) curve was 0.831 and yielded sensitivity of 77.4% and specificity of 87.1% at the predicted probability of 7.4 mm as the optimal cutoff point to access skin thickness. In the study, HFU was able to measure skin thickness, it correlated quantitatively with a valid measure of SSc activity, and a minimal detectable difference was identified. The online version of this article (10.1186/s13075-018-1686-9) contains supplementary material, which is available to authorized users.
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影响因子：
2
作者：
Khanna D;Furst DE;Clements PJ;Allanore Y;Baron M;Czirjak L;Distler O;Foeldvari I;Kuwana M;Matucci-Cerinic M;Mayes M;Medsger T Jr;Merkel PA;Pope JE;Seibold JR;Steen V;Stevens W;Denton CP
通讯作者：
Denton CP
影响因子：
--
作者：
van den Hoogen, Frank;Khanna, Dinesh;Fransen, Jaap;Johnson, Sindhu R.;Baron, Murray;Tyndall, Alan;Matucci-Cerinic, Marco;Naden, Raymond P.;Medsger, Thomas A., Jr.;Carreira, Patricia E.;Riemekasten, Gabriela;Clements, Philip J.;Denton, Christopher P.;Distler, Oliver;Allanore, Yannick;Furst, Daniel E.;Gabrielli, Armando;Mayes, Maureen D.;van Laar, Jacob M.;Seibold, James R.;Czirjak, Laszlo;Steen, Virginia D.;Inanc, Murat;Kowal-Bielecka, Otylia;Mueller-Ladner, Ulf;Valentini, Gabriele;Veale, Douglas J.;Vonk, Madelon C.;Walker, Ulrich A.;Chung, Lorinda;Collier, David H.;Csuka, Mary Ellen;Fessler, Barri J.;Guiducci, Serena;Herrick, Ariane;Hsu, Vivien M.;Jimenez, Sergio;Kahaleh, Bashar;Merkel, Peter A.;Sierakowski, Stanislav;Silver, Richard M.;Simms, Robert W.;Varga, John;Pope, Janet E.
通讯作者：
Pope, Janet E.
影响因子：
5.5
作者：
Hesselstrand, R.;Scheja, A.;Akesson, A.
通讯作者：
Akesson, A.
影响因子：
27.4
作者：
van den Hoogen, Frank;Khanna, Dinesh;Pope, Janet E.
通讯作者：
Pope, Janet E.
影响因子：
27.4
作者：
Kaloudi, Olga;Bandinelli, Francesca;Matucci-Cerinic, Marco
通讯作者：
Matucci-Cerinic, Marco