The Association of Remnant Cholesterol with Endothelial Dysfunction and Subclinical Atherosclerosis in a Check-Up Population in China.
The Association of Remnant Cholesterol with Endothelial Dysfunction and Subclinical Atherosclerosis in a Check-Up Population in China.
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DOI：
10.5551/jat.63695
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发表时间：
2023-06-01
影响因子：
4.4
通讯作者：
Shi QL
中科院分区：
文献类型：
--
作者：
Yang PT;Li Y;Wang JG;Zhang LJ;Yang SQ;Tang L;Chen Q;Shi QL
目的：血管内皮功能和动脉粥样硬化是心血管疾病的重要危险因素。然而，残留胆固醇（RC）是否与血管内皮功能和动脉粥样硬化（以血流介导的血管舒张（FMD）和肱-踝脉波速度（baPWV）为代表）相关尚不清楚。因此，在本研究中，我们的目的是在一般人群中调查这一点。方法：在这项研究中，我们检查了13237名接受血脂、FMD和baPWV测量的受试者。参与者根据RC四分位数分为四组。采用多变量线性回归模型，根据RC水平计算FMD和baPWV的优势比。结果：RC与FMD呈显著负相关（β= - 0.14,p=0.014），而RC与baPWV呈正相关（β=21.42,p<0.001），尤其是在男性和未服用慢性疾病药物的人群中。将人群按血脂分为3组：血脂异常组、非血脂异常但RC升高组（RC >0.78 mmol/L）、非血脂异常且RC正常组（RC≤0.78 mmol/L）。三组的FMD分别为7.09%±3.36%、7.39%±3.38%和7.57%±3.54%。三组患者的baPWV分别为1445.26±261.56 cm/s、1425.04±265.24 cm/s和1382.73±267.75 cm/s。两组之间存在显著差异。结论：研究结果表明，较高的RC是内皮功能和动脉粥样硬化参与者的独立预测因素。使用RC作为血管功能的风险管理指标是很重要的，特别是对于那些常规脂质参数正常但RC升高的患者。
Aim: Vascular endothelial function and atherosclerosis are known to be important risk factors for cardiovascular disease. However, it remains unknown whether remnant cholesterol (RC) correlates with vascular endothelial function and atherosclerosis as represented by flow-mediated vasodilation (FMD) and brachial-ankle pulse wave velocity (baPWV). Therefore, in this study, we aimed to investigate this in the general population. Methods: In this study, we examined 13,237 subjects who have undergone blood lipid, FMD, and baPWV measurements. Participants were divided into four groups based on RC quartiles. Multivariable linear regression models were used to calculate odds ratios for FMD and baPWV according to the RC levels. Results: A significant negative relationship was found between RC and FMD (β=−0.14,p=0.014), whereas RC was positively associated with baPWV (β=21.42,p＜0.001), especially in the male and without chronic disease medication populations. The population was divided into three groups according to their lipids: dyslipidemia group, nondyslipidemia but RC increased group (RC ＞0.78 mmol/L), and nondyslipidemia and RC normal group (RC ≤ 0.78 mmol/L). The FMD of the three groups was 7.09%±3.36%, 7.39%±3.38%, and 7.57%±3.54%, respectively. The baPWV of the three groups was 1445.26±261.56 cm/s, 1425.04±265.24 cm/s, and 1382.73±267.75 cm/s. Significant differences were noted between the groups. Conclusions: The findings indicated that a higher RC was an independent predictive factor for participants with endothelial function and atherosclerosis. It is important to use RC as a risk management indicator of vascular function, especially for those with normal conventional lipid parameters but increased RC.
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