The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela.
The Divergent Pattern of SARS-CoV-2 Variant Predominance and Transmission Dynamics in the Brazilian Island of Ilhabela.
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DOI：
10.3390/v14071481
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发表时间：
2022-07-05
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--
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我们在巴西开展的SARS-CoV-2基因组监测工作发现，在伽马挥发性有机化合物已经在大陆占主导地位的情况下，在Ilhabela岛（<s:1>圣保罗州）人口中发现了值得关注的α变体，其优势高于75%，这引起了对该岛屿进行更密切监测的关注。因此，我们加强了24周的监测，收集了34%的当地阳性病例的数据。我们的数据表明，VOC优势动态和感染率的模式总体上与大陆不同。我们在此报告了巴西人群中已知的第一个Alpha优势病例，与大陆相比，Gamma在之前的变体中占主导地位的延迟超过3个月，并且与大陆相比，Gamma和Delta挥发性有机化合物的扩散速度更快。系统发育分析显示，伊哈贝拉地区SARS-CoV-2的传播动力学特征为多个独立的Gamma和Delta传入事件，α传入事件较少，其中两个事件随后发生社区传播。这项研究证明了SARS-CoV-2变体在孤立人群中的特殊行为，并揭示了在孤立人群中进行SARS-CoV-2基因组监测的特定计划的重要性。
Our effort in SARS-CoV-2 genomic surveillance in Brazil has detected the Alpha Variant of Concern with a predominance higher than 75% in the population of Ilhabela island (São Paulo State) at a time when the Gamma VOC was already predominating the mainland raised concerns for closer surveillance on this island. Therefore, we intensified the surveillance for 24 weeks by generating data from 34% of local positive cases. Our data show that the patterns of VOC predominance dynamics and infection rates were in general distinct from the mainland. We report here the first known case of Alpha predominance in a Brazilian population, a delay greater than 3 months for the Gamma to dominate the previous variants compared to the mainland, and a faster dispersion rate of Gamma and Delta VOCs compared to the mainland. Phylogenetic analysis revealed the SARS-CoV-2 transmission dynamics in Ilhabela were characterized by multiple independent introduction events of Gamma and Delta, with a few events of Alpha introduction, two of them followed by community transmission. This study evidenced the peculiar behavior of SARS-CoV-2 variants in an isolated population and brought to light the importance of specific programs for SARS-CoV-2 genomic surveillance in isolated populations.
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影响因子：
3.7
作者：
Walker BJ;Abeel T;Shea T;Priest M;Abouelliel A;Sakthikumar S;Cuomo CA;Zeng Q;Wortman J;Young SK;Earl AM
通讯作者：
Earl AM
影响因子：
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作者：
O'Toole, Aine;Hill, Verity;Kraemer, Moritz U G
通讯作者：
Kraemer, Moritz U G
影响因子：
5.3
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通讯作者：
de Alcantara LCJ
影响因子：
10.7
作者：
Nguyen LT;Schmidt HA;von Haeseler A;Minh BQ
通讯作者：
Minh BQ
影响因子：
2.8
作者：
Stirling C;Andrews S;Croft T;Vickers J;Turner P;Robinson A
通讯作者：
Robinson A