Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated.
Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated.
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DOI：
10.1016/j.virol.2005.11.044
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发表时间：
2006-04-10
期刊：
影响因子：
3.7
通讯作者：
Perlman S
中科院分区：
文献类型：
--
作者：
Butler N;Pewe L;Trandem K;Perlman S
人类冠状病毒HCoV-OC43导致很大一部分上呼吸道感染。大多数冠状病毒表现出很强的物种特异性，尽管sars冠状病毒是与棕榈果子狸的物种交叉感染人类的。同样，HCoV-OC43很可能与SARS-CoV属于同一冠状病毒群，它很容易跨越物种屏障，这可以从它对小鼠大脑的快速适应中得到证明[McIntosh， K., Becker， W.B., Chanock， R.M., 1967]。来自上呼吸道疾病患者的ibv样病毒在哺乳小鼠脑内的生长美国科学学报，58(2):668 - 673。在此，我们研究了这种可塑性在物种向性中的两个后果。首先，我们发现HCoV-OC43能够感染来自大量哺乳动物物种的细胞。其次，我们发现仅在哺乳小鼠大脑中传播的病毒具有高毒性，并在成年小鼠中引起一致致命的脑炎。表面糖蛋白是大多数冠状病毒感染的主要毒力因子。我们发现HCoV-OC43表面糖蛋白的三种变化与小鼠神经毒力增强相关；它们位于负责与宿主细胞结合的蛋白质区域。这些数据表明，一些冠状病毒，包括HCoV-OC43和SARS-CoV，很容易适应在异源物种的细胞中生长。这种适应性有助于分离出感染动物和组织培养细胞的能力明显不同的HCoV-OC43病毒变体。
The human coronavirus HCoV-OC43 causes a significant fraction of upper respiratory tract infections. Most coronaviruses show a strong species specificity, although the SARS-Coronavirus crossed species from palm civet cats to infect humans. Similarly, HCoV-OC43, likely a member of the same coronavirus group as SARS-CoV, readily crossed the species barrier as evidenced by its rapid adaptation to the murine brain [McIntosh, K., Becker, W.B., Chanock, R.M., 1967. Growth in suckling-mouse brain of “IBV-like” viruses from patients with upper respiratory tract disease. Proc Natl Acad Sci U.S.A. 58, 2268–73]. Herein, we investigated two consequences of this plasticity in species tropism. First, we showed that HCoV-OC43 was able to infect cells from a large number of mammalian species. Second, we showed that virus that was passed exclusively in suckling mouse brains was highly virulent and caused a uniformly fatal encephalitis in adult mice. The surface glycoprotein is a major virulence factor in most coronavirus infections. We identified three changes in the HCoV-OC43 surface glycoprotein that correlated with enhanced neurovirulence in mice; these were located in the domain of the protein responsible for binding to host cells. These data suggest that some coronaviruses, including HCoV-OC43 and SARS-CoV, readily adapt to growth in cells from heterologous species. This adaptability has facilitated the isolation of HCoV-OC43 viral variants with markedly differing abilities to infect animals and tissue culture cells.
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影响因子：
64.8
作者：
Li W;Moore MJ;Vasilieva N;Sui J;Wong SK;Berne MA;Somasundaran M;Sullivan JL;Luzuriaga K;Greenough TC;Choe H;Farzan M
通讯作者：
Farzan M
影响因子：
11.4
作者：
Li, WH;Zhang, CS;Sui, JH;Kuhn, JH;Moore, MJ;Luo, SW;Wong, SK;Huang, IC;Xu, KM;Vasilieva, N;Murakami, A;He, YQ;Marasco, WA;Guan, Y;Choe, HY;Farzan, M
通讯作者：
Farzan, M
影响因子：
5.4
作者：
Brynes, AP;Griffin, DE
通讯作者：
Griffin, DE
DOI：
10.1073/pnas.58.6.2268
发表时间：
1967-01-01
影响因子：
11.1
作者：
MCINTOSH, K;BECKER, WB;CHANOCK, RM
通讯作者：
CHANOCK, RM
多器官感染和SAR的发病机理。
影响因子：
15.3
作者：
Gu, Jiang;Gong, Encong;Zhang, Bo;Zheng, Jie;Gao, Zifen;Zhong, Yanfeng;Zou, Wanzhong;Zhan, Jun;Wang, Shenglan;Xie, Zhigang;Zhuang, Hui;Wu, Bingquan;Zhong, Haohao;Shao, Hongquan;Fang, Weigang;Gao, Dongshia;Pei, Fei;Li, Xingwang;He, Zhongpin;Xu, Danzhen;Shi, Xeying;Anderson, Virginia M;Leong, Anthony S-Y
通讯作者：
Leong, Anthony S-Y