Revisiting the role of the Himalayas in peopling Nepal: insights from mitochondrial genomes
Revisiting the role of the Himalayas in peopling Nepal: insights from mitochondrial genomes
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重新审视喜马拉雅山在尼泊尔人口中的作用：线粒体基因组的见解
DOI：
10.1038/jhg.2012.8
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发表时间：
2012-03
影响因子：
3.5
通讯作者：
Kong, Q-P
中科院分区：
文献类型：
--
作者：
Wang, H-W;Zhang, Y-P;Li, Y-C;Sun, Fei;Zhao, M;Mitra, B;Chaudhuri, T-K;Regmi, P;Wu, S-F;Kong, Q-P
喜马拉雅山被认为是南亚和东亚之间的一道强大的地理屏障。在尼泊尔观察到的东欧亚父系谱系的高频率导致一些研究人员认为这些谱系是直接从西藏引入尼泊尔的;然而，东欧亚遗传成分也可能追溯到印度东北部，那里已经检测到了丰富的东欧亚母系谱系。为了追踪尼泊尔母系遗传成分的起源，特别是东欧亚血统的起源，然后更好地了解喜马拉雅山脉在尼泊尔人口中的作用，我们广泛研究了尼泊尔及其周围人群的母系遗传成分，特别是东欧亚血统。我们的研究结果揭示了尼泊尔人和西藏人之间的密切关系，特别是，东欧亚血统的尼泊尔血统通常与西藏血统在遗传学上更接近，尽管尼泊尔人和东北印度人之间共享了一些线粒体DNA单倍型，可能是由于最近的基因流动。看来，西藏是最有可能成为大多数东欧亚在尼泊尔的家园。考虑到先前对Y染色体的观察，现在令人信服的是，东欧亚遗传成分的携带者在大约6千年前（kya）穿过喜马拉雅山脉进入尼泊尔，这一情景与语言学和考古学的先前结果非常一致。
Himalayas was believed to be a formidably geographical barrier between South and East Asia. The observed high frequency of the East Eurasian paternal lineages in Nepal led some researchers to suggest that these lineages were introduced into Nepal from Tibet directly; however, it is also possible that the East Eurasian genetic components might trace their origins to northeast India where abundant East Eurasian maternal lineages have been detected. To trace the origin of the Nepalese maternal genetic components, especially those of East Eurasian ancestry, and then to better understand the role of the Himalayas in peopling Nepal, we have studied the matenal genetic composition extensively, especially the East Eurasian lineages, in Nepalese and its surrounding populations. Our results revealed the closer affinity between the Nepalese and the Tibetans, specifically, the Nepalese lineages of the East Eurasian ancestry generally are phylogenetically closer with the ones from Tibet, albeit a few mitochondrial DNA haplotypes, likely resulted from recent gene flow, were shared between the Nepalese and northeast Indians. It seems that Tibet was most likely to be the homeland for most of the East Eurasian in the Nepalese. Taking into account the previous observation on Y chromosome, now it is convincing that bearer of the East Eurasian genetic components had entered Nepal across the Himalayas around 6 kilo years ago (kya), a scenario in good agreement with the previous results from linguistics and archeology.
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影响因子：
1.8
作者：
Thangaraj, Kumarasamy;Chaubey, Gyaneshwer;Kivisild, Toomas;Rani, Deepa Selvi;Singh, Vijay Kumar;Ismail, Thanseem;Carvalho-Silva, Denise;Metspalu, Mait;Bhaskar, L. V. K. S.;Reddy, Alla G.;Chandra, Sarat;Pande, Veena;Naidu, B. Prathap;Adarsh, Niharika;Verma, Abhilasha;Jyothi, Inaganti Amara;Mallick, Chandana Basu;Shrivastava, Nidhi;Devasena, Ragala;Kumari, Babita;Singh, Amit Kumar;Dwivedi, Shailendra Kumar Dhar;Singh, Shefali;Rao, Geeta;Gupta, Pranav;Sonvane, Vartika;Kumari, Kavita;Basha, Afsar;Bhargavi, K. R.;Lalremruata, Albert;Gupta, Arvind Kumar;Kaur, Gurukamal;Reddy, K. K.;Rao, A. Papa;Villems, Richard;Tyler-Smith, Chris;Singh, Lalji
通讯作者：
Singh, Lalji
影响因子：
2.9
作者：
Chan WM;Andrews C;Dragan L;Fredrick D;Armstrong L;Lyons C;Geraghty MT;Hunter DG;Yazdani A;Traboulsi EI;Pott JW;Gutowski NJ;Ellard S;Young E;Hanisch F;Koc F;Schnall B;Engle EC
通讯作者：
Engle EC
影响因子：
56.9
作者：
Macaulay, V;Hill, C;Richards, M
通讯作者：
Richards, M
影响因子：
10.7
作者：
Hill, Catherine;Soares, Pedro;Richards, Martin
通讯作者：
Richards, Martin
追踪南岛人在东南亚大陆的足迹：线粒体 DNA 的视角
影响因子：
10.7
作者：
Peng, Min-Sheng;Huy Ho Quang;Zhang, Ya-Ping
通讯作者：
Zhang, Ya-Ping