Gene duplication and environmental adaptation within yeast populations.
Gene duplication and environmental adaptation within yeast populations.
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DOI：
10.1093/gbe/evq043
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发表时间：
2010
影响因子：
3.3
通讯作者：
Lovell SC
中科院分区：
文献类型：
--
作者：
Ames RM;Rash BM;Hentges KE;Robertson DL;Delneri D;Lovell SC
由基因复制和丢失引起的基因拷贝数的群体水平差异最近被认为是真核生物变异的重要来源。然而，除了少数情况下，这种变异的表型效应是未知的。酵母菌基因组重测序项目的数据允许研究同一种群中一组个体的基因组序列重复。这些序列可以与这些酵母菌株分离的环境的可用信息相关联。我们发现，酵母显示出丰富的重复基因是谱系特异性的，导致个体菌株之间的基因含量有很大程度的变化。对于特定功能存在可检测的偏倚，表明选择优先保留某些重复。最引人注目的是，我们发现，套过度和代表性不足的重复与环境，他们被隔离。总之，这些观察结果表明，基因复制可以引起种群内的大量表型差异，这反过来又可以提供进化适应的捷径。
Population-level differences in the number of copies of genes resulting from gene duplication and loss have recently been recognized as an important source of variation in eukaryotes. However, except for a small number of cases, the phenotypic effects of this variation are unknown. Data from the Saccharomyces Genome Resequencing Project permit the study of duplication in genome sequences from a set of individuals within the same population. These sequences can be correlated with available information on the environments from which these yeast strains were isolated. We find that yeast show an abundance of duplicate genes that are lineage specific, leading to a large degree of variation in gene content between individual strains. There is a detectable bias for specific functions, indicating that selection is acting to preferentially retain certain duplicates. Most strikingly, we find that sets of over- and underrepresented duplicates correlate with the environment from which they were isolated. Together, these observations indicate that gene duplication can give rise to substantial phenotypic differences within populations that in turn can offer a shortcut to evolutionary adaptation.
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影响因子：
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