Independent Association between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: A Systematic Review and Meta-Analysis.
Independent Association between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: A Systematic Review and Meta-Analysis.
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DOI：
10.1155/2013/124958
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发表时间：
2013
影响因子：
2.8
通讯作者：
Sun L
中科院分区：
文献类型：
--
作者：
Lu H;Liu H;Hu F;Zou L;Luo S;Sun L
非酒精性脂肪性肝病（NAFLD）与胰岛素抵抗和一些代谢综合征特征密切相关，但它是否会增加心血管疾病的风险仍不确定。为了评估NAFLD与心血管结局风险之间的相关性，我们使用医学主题标题检索词和标准化方案系统检索了MEDLINE、Embase和科克伦图书馆数据库（1947年至2012年10月）。在成人中进行的随机对照试验、病例对照和前瞻性研究，其中报告了NAFLD心血管疾病的未校正和多变量校正比值比及其相应的95%置信区间（CI）。检索产生了4项横断面研究和2项前瞻性队列研究，包括7，042名参与者。合并效应估计值显示NAFLD是心血管疾病的预测因子（优势比1.88，95%CI，1.68 - 2.01; P < 0.001）。随机效应汇总估计表明，在调整了已确定的心血管危险因素后，NAFLD与心血管结局保持显著相关，与传统危险因素无关（比值比1.50，95%CI，1.21至1.87; P < 0.001）。这些结果表明，NAFLD是心血管疾病的一个强有力的独立预测因子，并可能在代谢综合征的心血管风险中发挥核心作用。
Nonalcoholic fatty liver disease (NAFLD) is closely correlated with insulin resistance and several metabolic syndrome features, but whether it could increase the risk of cardiovascular disease remains undefined. To assess the association between NAFLD and the risk of cardiovascular outcomes, we systematically searched the MEDLINE, Embase, and the Cochrane Library database (1947 to October 2012) by using Medical Subject Heading search terms and a standardized protocol. Randomized controlled trials, case-control, and prospective studies carried out in human adults, in which the unadjusted and multivariate adjusted odds ratios with corresponding 95% confidence interval (CI) for cardiovascular disease with NAFLD were reported. The search yielded 4 cross-sectional studies and 2 prospective cohort studies including 7,042 participants. The pooled effects estimate showed that NAFLD was a predictor of cardiovascular disease (odds ratio 1.88, 95% CI, 1.68 to 2.01; P < 0.001). The random effects summary estimate indicated that NAFLD retained a significant association with cardiovascular outcomes independent of conventional risk factors after adjustment for established cardiovascular risk factors (odds ratio 1.50, 95% CI, 1.21 to 1.87; P < 0.001). These results indicate that NAFLD is a strong independent predictor of cardiovascular disease and may play a central role in the cardiovascular risk of metabolic syndrome.
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非酒精性脂肪肝病与冠状动脉钙化有关。
影响因子：
13.5
作者：
Kim, Donghee;Choi, Su-Yeon;Park, Eun Ha;Lee, Whal;Kang, Jin Hwa;Kim, Won;Kim, Yoon Jun;Yoon, Jung-Hwan;Jeong, Sook Hyang;Lee, Dong Ho;Lee, Hyo-suk;Larson, Joseph;Therneau, Terry M.;Kim, W. Ray
通讯作者：
Kim, W. Ray
影响因子：
7.7
作者：
Targher, G;Bertolini, L;Falezzal, G
通讯作者：
Falezzal, G
DOI：
10.1016/j.bpg.2010.08.005
发表时间：
2010-10-01
影响因子：
3.2
作者：
Krawczyk, Marcin;Bonfrate, Leonilde;Portincasa, Piero
通讯作者：
Portincasa, Piero
影响因子：
2.9
作者：
Li, Wei;Ma, Dongrui;Zhang, Shihong
通讯作者：
Zhang, Shihong
影响因子：
13.5
作者：
Browning, JD;Szczepaniak, LS;Hobbs, HH
通讯作者：
Hobbs, HH