Nonalcoholic fatty liver disease is associated with coronary artery calcification.
Nonalcoholic fatty liver disease is associated with coronary artery calcification.
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非酒精性脂肪肝病与冠状动脉钙化有关。
DOI：
10.1002/hep.25593
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发表时间：
2012-08
期刊：
影响因子：
13.5
通讯作者：
Kim, W. Ray
中科院分区：
文献类型：
--
作者：
Kim, Donghee;Choi, Su-Yeon;Park, Eun Ha;Lee, Whal;Kang, Jin Hwa;Kim, Won;Kim, Yoon Jun;Yoon, Jung-Hwan;Jeong, Sook Hyang;Lee, Dong Ho;Lee, Hyo-suk;Larson, Joseph;Therneau, Terry M.;Kim, W. Ray
非酒精性脂肪性肝病(NAFLD)与冠状动脉疾病的危险因素有关，如血脂异常、糖尿病、代谢综合征等，这些因素与内脏肥胖密切相关。这项研究的目的是调查NAFLD是否与冠状动脉钙化(CAC)有关，CAC是独立于CT测量的内脏脂肪而被用作冠状动脉粥样硬化的替代标志物。在2003至2008年间访问健康筛查中心的5648名受试者中，我们招募了4023名(平均年龄56.9±9.4岁，60.7%的男性)没有已知肝病或缺血性心脏病病史的受试者。CAC评分采用Agatston法。在单变量分析中，CAC(0分)的存在与年龄、性别、体重指数、天冬氨酸氨基转移酶、丙氨酸氨基转移酶、高密度脂蛋白胆固醇、甘油三酯以及糖尿病、高血压、吸烟和非酒精性脂肪肝的风险增加显著相关。CAC值的增加(0.001，10，10-100，≥100)与非酒精性脂肪肝的高患病率相关(OR1.84，95%可信区间1.61-2.10，P<；100)。在校正了传统危险因素和CT测量内脏脂肪组织面积的多变量有序回归分析中，CAC评分的增加与NAFLD的存在显著相关(OR1.28，95%CI1.04~1.59，P=0.023)，而与内脏肥胖无关。NAFLD患者发生冠状动脉粥样硬化的风险增加，独立于经典的冠状动脉危险因素，包括内脏肥胖症。这些数据表明NAFLD本身可能是冠状动脉疾病的独立危险因素。
Nonalcoholic fatty liver disease (NAFLD) is related to risk factors of coronary artery disease, such as dyslipidemia, diabetes, and metabolic syndrome, which are closely linked with visceral adiposity. The aim of this study was to investigate whether NAFLD was associated with coronary artery calcification (CAC), which is used as a surrogate marker for coronary atherosclerosis independent of computed tomography (CT)-measured visceral adiposity. Out of 5,648 subjects who visited one of health screening centers between 2003 and 2008, we enrolled 4,023 (mean age 56.9 ± 9.4 years, 60.7% males) subjects without known liver disease or a history of ischemic heart disease. CAC score was evaluated by the Agatston method. In univariate analyses, the presence of CAC (score >0) was significantly associated with age, sex, body mass index, aspartate aminotransferase, alanine aminotransferase, high-density lipoprotein cholesterol, triglycerides and increased odds of diabetes, hypertension, smoking, and NAFLD. Increasing CAC scores (0, <10, 10-100, ≥100) were associated with higher prevalence of NAFLD (OR 1.84, 95% CI 1.61-2.10, P<0.001). Multivariate ordinal regression analysis adjusted for traditional risk factors, and CT-measured visceral adipose tissue area in a subgroup of subjects showed that the increased CAC scores were significantly associated with the presence of NAFLD (OR 1.28, 95% CI 1.04-1.59, P=0.023) independent of visceral adiposity. Patients with NAFLD are at increased risk for coronary atherosclerosis independent of classical coronary risk factors, including visceral adiposity. These data suggest that NAFLD per se might be an independent risk factor for coronary artery disease.
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DOI：
10.1161/01.atv.0000160613.57985.18
发表时间：
2005-05-01
影响因子：
8.7
作者：
Brea, A;Mosquera, D;Ros, E
通讯作者：
Ros, E
影响因子：
13.5
作者：
Browning, JD;Szczepaniak, LS;Hobbs, HH
通讯作者：
Hobbs, HH
影响因子：
120.7
作者：
Greenland, P;LaBree, L;Detrano, RC
通讯作者：
Detrano, RC
影响因子：
158.5
作者：
Detrano, Robert;Guerci, Alan D.;Kronmal, Richard A.
通讯作者：
Kronmal, Richard A.
影响因子：
6.8
作者：
Jung, Dong-Hyuk;Lee, Yong-Jae;Lee, Hye-Ree
通讯作者：
Lee, Hye-Ree