Effects of Dmo1 on obesity, dyslipidaemia and hyperglycaemia in the Otsuka Long Evans Tokushima Fatty strain.
Effects of Dmo1 on obesity, dyslipidaemia and hyperglycaemia in the Otsuka Long Evans Tokushima Fatty strain.
复制标题
Dmo1 对 Otsuka Long Evans Tokushima Fatty 菌株肥胖、血脂异常和高血糖的影响。
DOI：
--
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
A. Tanigami
中科院分区：
文献类型：
--
作者：
S. Okuno;T. Watanabe;T. Ono;K. Oga;A. Mizoguchi‐Miyakita;Y. Yamasaki;Y. Goto;H. Shinomiya;H. Momota;H. Miyao;I. Hayashi;T. Asai;M. Suzuki;Y. Harada;H. Hishigaki;S. Wakitani;T. Takagi;Y. Nakamura;A. Tanigami
全基因组扫描已经确定Dmo1是大冢龙埃文斯德岛脂肪（OLETF）大鼠肥胖和血脂异常的主要数量性状位点（QTL）。我们利用标记辅助的快速同源协议，通过选择性去除其他QTL区域（QTL标记辅助反选择），生产了Dmo1基因座的同源大鼠，以有效地将非糖尿病Fischer 344 （F344）大鼠的染色体片段转移到OLETF背景中。在第三代遗传动物中，我们观察到Dmo1位点在脂质代谢、肥胖控制和血糖稳态方面具有显著的治疗作用。我们得出结论，尽管II型糖尿病综合征具有复杂的多基因性质，但对受损遗传途径的单等位基因校正可以产生实质性的治疗效果。
Whole-genome scans have identified Dmo1 as a major quantitative trait locus (QTL) for obesity and dyslipidaemia in the Otsuka Long Evans Tokushima Fatty (OLETF) rat. We have produced congenic rats for the Dmo1 locus, using marker-assisted speed congenic protocols, enforced by selective removal of other QTL regions (QTL-marker-assisted counterselection), to efficiently transfer chromosomal segments from non-diabetic Fischer 344 (F344) rats into the OLETF background. In the third generation of congenic animals, we observed a substantial therapeutic effect of the Dmo1 locus on lipid metabolism, obesity control and plasma glucose homeostasis. We conclude that single-allele correction of an impaired genetic pathway can generate a substantial therapeutic effect, despite the complex polygenic nature of type II diabetic syndromes.
影响因子：
7
作者：
R. Steen;A. Kwitek-Black;Christopher Glenn;J. Gullings-Handley;W. V. Etten;O. Atkinson;D. Appel;S. Twigger;Melanie Muir;Tim Mull;M. Granados;Mushira Kissebah;Kerri Russo;Robbin Crane;M. Popp;M. Peden;T. Matise;Donna M. Brown;Jian Lu;S. Kingsmore;P. Tonellato;S. Rozen;D. Slonim;Peter Young;M. Knoblauch;A. Provoost;Detlev Ganten;S. Colman;J. Rothberg;E. Lander;H. Jacob
通讯作者：
R. Steen;A. Kwitek-Black;Christopher Glenn;J. Gullings-Handley;W. V. Etten;O. Atkinson;D. Appel;S. Twigger;Melanie Muir;Tim Mull;M. Granados;Mushira Kissebah;Kerri Russo;Robbin Crane;M. Popp;M. Peden;T. Matise;Donna M. Brown;Jian Lu;S. Kingsmore;P. Tonellato;S. Rozen;D. Slonim;Peter Young;M. Knoblauch;A. Provoost;Detlev Ganten;S. Colman;J. Rothberg;E. Lander;H. Jacob
肾素基因转移对自发性高血压大鼠血压的影响。
DOI：
10.1161/01.hyp.31.1.373
发表时间：
1998
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
StLezin,E;Liu,W;Wang,N;Wang,JM;Kren,V;Zidek,V;Zdobinska,M;Krenova,D;Bottger,A;vanZutphen,BF;Pravenec,M
通讯作者：
Pravenec,M