A review of gene and stem cell therapy in cutaneous wound healing.
A review of gene and stem cell therapy in cutaneous wound healing.
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DOI：
10.1016/j.burns.2008.03.009
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Jeschke MG
中科院分区：
文献类型：
--
作者：
Branski LK;Gauglitz GG;Herndon DN;Jeschke MG
在过去的几十年里，已经提出了不同的治疗方法来调节伤口修复。本文综述了基因和干细胞治疗在伤口愈合中的两个新兴领域。基因治疗最初是为治疗先天性缺陷而发展起来的，是一种增强伤口修复的新选择。为了加速伤口愈合，编码生长因子或细胞因子的基因显示出最大的潜力。大多数基因传递系统是基于病毒转染，裸DNA应用，高压注射，或脂质体载体。胚胎和成体干细胞具有较长的自我更新能力，能够分化成各种组织类型。骨髓、外周血、脐带血、脂肪组织、皮肤和毛囊等多种来源已被用于分离干细胞，以调节急性和慢性伤口的愈合反应。最近，基因和干细胞治疗的结合已成为未来治疗慢性和急性伤口的一种有希望的方法。
Different therapies that modulate wound repair have been proposed over the last few decades. This article reviews the two emerging fields of gene and stem cell therapy in wound healing. Gene therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines have showed the most potential. The majority of gene delivery systems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult stem cells have a prolonged self renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate stem cells to modulate the healing response of acute and chronic wounds. Recently, the combination of gene and stem cell therapy has emerged as a promising approach for future treatment of chronic and acute wounds.
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影响因子：
3.5
作者：
ALEXANDER, MY;AKHURST, RJ
通讯作者：
AKHURST, RJ
影响因子：
6.5
作者：
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DOI：
10.1097/00005373-199512000-00023
发表时间：
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影响因子：
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作者：
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通讯作者：
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作者：
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