Malaria inhibits surface expression of complement receptor 1 in monocytes/macrophages, causing decreased immune complex internalization.
Malaria inhibits surface expression of complement receptor 1 in monocytes/macrophages, causing decreased immune complex internalization.
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DOI：
10.4049/jimmunol.1103812
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发表时间：
2013-04-01
期刊：
影响因子：
--
通讯作者：
Rodriguez A
中科院分区：
文献类型：
--
作者：
Fernandez-Arias C;Lopez JP;Hernandez-Perez JN;Bautista-Ojeda MD;Branch O;Rodriguez A
在吞噬细胞表面表达的补体受体1（CR 1）结合补体结合的IC，在循环免疫复合物（IC）的清除中起重要作用。这种受体对于防止IC的积累至关重要，IC的积累可导致炎症病理学。在疟疾期间经常观察到循环IC的积累，尽管导致这种积累的因素尚不清楚。我们已经观察到，在感染约氏疟原虫的小鼠（啮齿动物疟疾模型）中，单核细胞/巨噬细胞和B细胞上的CR 1表面表达强烈降低。来自这些感染小鼠的单核细胞/巨噬细胞对由CR 1表达降低引起的补体介导的IC内化具有特异性抑制作用。因此，小鼠显示出循环IC的积累和IC在肾脏中的沉积，这与CR 1表面表达的降低负相关。我们的研究结果表明，疟疾诱导单核细胞/巨噬细胞群体中的表面CR 1表达显著降低，导致单核细胞/巨噬细胞对IC的内化不足。为了确定这种现象是否在人类疟疾患者中发现，我们分析了92名感染恶性疟原虫（22）或间日疟原虫（70）的患者，这是最流行的人类疟疾寄生虫。这些患者的外周单核细胞/巨噬细胞和B细胞上的表面CR 1水平与相同区域中未感染的对照个体相比显示出显著降低。我们认为，CR 1的这种减少在疟疾期间IC清除受损中起着至关重要的作用。
Complement receptor 1 (CR1) expressed on the surface of phagocytic cells binds complement-bound IC playing an important role in the clearance of circulating immunecomplexes (IC). This receptor is critical to prevent accumulation of IC, which can contribute to inflammatory pathology. Accumulation of circulating IC is frequently observed during malaria, although the factors contributing to this accumulation are not clearly understood. We have observed that the surface expression of CR1 on monocyte/macrophages and B cells is strongly reduced in mice infected with Plasmodium yoelii, a rodent malaria model. Monocyte/macrophages from these infected mice present a specific inhibition of complement-mediated internalization of IC caused by the decreased CR1 expression. Accordingly, mice show accumulation of circulating IC and deposition of IC in the kidneys that inversely correlates with the decrease in CR1 surface expression. Our results indicate that malaria induces a significant decrease on surface CR1 expression in the monocyte/macrophage population that results in deficient internalization of IC by monocyte/macrophages. To determine whether this phenomenon is found in human malaria patients, we have analyzed 92 patients infected with either P. falciparum (22) or P. vivax (70), the most prevalent human malaria parasites. The levels of surface CR1 on peripheral monocyte/macrophages and B cells of these patients show a significant decrease compared to uninfected control individuals in the same area. We propose that this decrease in CR1 plays an essential role in impaired IC clearance during malaria.
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DOI：
10.4269/ajtmh.2005.72.593
发表时间：
2005-05-01
影响因子：
3.3
作者：
Mibei, EK;Orago, ASS;Stoute, JA
通讯作者：
Stoute, JA
影响因子：
4.4
作者：
Arias, Cristina F.;Ballesteros-Tato, Andre;Balomenos, Dimitrios
通讯作者：
Balomenos, Dimitrios
影响因子：
3.5
作者：
Eisenhut, Michael
通讯作者：
Eisenhut, Michael
影响因子：
3.6
作者：
Nardin, A;Lindorfer, MA;Taylor, RP
通讯作者：
Taylor, RP
影响因子：
5.6
作者：
Liu, Guangwei;Xia, Xue-Pei;Zhao, Yong
通讯作者：
Zhao, Yong