Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review.
Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review.
复制标题
是时候评估寨卡病毒垂直传播的临床影响了吗？系统评价。
DOI：
10.3389/fpsyt.2021.699115
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发表时间：
2021
影响因子：
4.7
通讯作者：
Moreira MEL
中科院分区：
文献类型：
--
作者：
do Amaral YNDV;Malacarne J;Brandão PG;Brasil P;Nielsen-Saines K;Moreira MEL
背景：寨卡病毒（ZIKV）的垂直传播可能与新生儿的多种临床特征有关。本综述的目的是分析目前对 3 岁以下儿童围产期接触 ZIKV 后临床影响的了解。方法：对 PubMed、虚拟健康图书馆 (BVS)、Scopus 和 Web of Science 数据库以及 CAPES 论文目录中确定的已发表研究进行系统回顾，不受语言或发表日期的限制。根据建议的流程图，书目检索得到了 1,563 篇论文。其中，根据合格标准，选择70个进行系统评价；所有论文均于 2016 年至 2021 年间发表。 结果：关于临床发现，19 篇论文评估了临床影像学改变，21 篇论文评估了眼科表现，39 篇论文评估了中枢神经系统；其中 15 人分析了神经精神运动发育。其余的评估了听力学（n = 14）、营养学（n = 14）、骨科（n = 7）、心肺（n = 5）、泌尿生殖（n = 3）或内分泌（n = 1）表现。结论：考虑到 ZIKV 的长期影响未知以及妊娠期间这种感染的已知产后并发症，研究继续监测产前 ZIKV 暴露儿童的成长至关重要。为了描述儿童整个疾病谱的特征，对观察到的临床结果进行更广泛的描述也很重要。系统审查注册：PROSPERO 注册：CRD42020205947。
Background: Vertical transmission of Zika Virus (ZIKV) can be associated with several clinical features in newborn infants. The goal of the present review was to analyze the current state of knowledge regarding clinical repercussions following perinatal exposure to ZIKV in children up to 3 years of age. Methods: A systematic review of published studies was carried out, without the restriction of language or date of publication, identified in the databases PubMed, Virtual Health Library (BVS), Scopus, and Web of Science and the catalog for CAPES theses and dissertations. According to the proposed flowchart, the bibliographic search resulted in 1,563 papers. Of these, according to the eligibility criteria, 70 were selected for systematic review; all were published between 2016 and 2021. Results: Regarding clinical findings, 19 papers evaluated clinical imaging alterations, 21 ophthalmic manifestations, and 39 evaluated the central nervous system; of these, 15 analyzed neuro-psychomotor development. The remainder evaluated audiological (n = 14), nutritional (n = 14), orthopedic (n = 7), cardiorespiratory (n = 5), genitourinary (n = 3) or endocrinological (n = 1) manifestations. Conclusion: It is critical for studies to continue monitoring children with antenatal ZIKV exposure as they grow, given the unknown long-term repercussions of ZIKV and the recognized postnatal complications of this infection during pregnancy. Broader descriptions of observed clinical findings are also important in order to characterize the entire spectrum of disease in children. Systematic Review Registration: PROSPERO REGISTER: CRD42020205947.
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DOI：
10.1056/nejmoa1602412
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brasil P;Pereira JP Jr;Moreira ME;Ribeiro Nogueira RM;Damasceno L;Wakimoto M;Rabello RS;Valderramos SG;Halai UA;Salles TS;Zin AA;Horovitz D;Daltro P;Boechat M;Raja Gabaglia C;Carvalho de Sequeira P;Pilotto JH;Medialdea-Carrera R;Cotrim da Cunha D;Abreu de Carvalho LM;Pone M;Machado Siqueira A;Calvet GA;Rodrigues Baião AE;Neves ES;Nassar de Carvalho PR;Hasue RH;Marschik PB;Einspieler C;Janzen C;Cherry JD;Bispo de Filippis AM;Nielsen-Saines K
通讯作者：
Nielsen-Saines K
影响因子：
8.4
作者：
Carvalho-Sauer, Rita;Nascimento Costa, Maria da Conceicao;Teixeira, Maria Gloria
通讯作者：
Teixeira, Maria Gloria
DOI：
10.3390/ijerph15061107
发表时间：
2018-06-01
影响因子：
--
作者：
Confessor Ferreira, Haryelle Naryma;Schiariti, Veronica;Longo, Egmar
通讯作者：
Longo, Egmar
影响因子：
3.3
作者：
de Vasconcelos, Romulo A. L.;Ximenes, Ricardo A. A.;Miranda-Filho, Democrito de B.
通讯作者：
Miranda-Filho, Democrito de B.
影响因子：
168.9
作者：
Franca, Giovanny V. A.;Schuler-Faccini, Lavinia;Victora, Cesar G.
通讯作者：
Victora, Cesar G.