Living near a Major Road in Beijing: Association with Lower Lung Function, Airway Acidification, and Chronic Cough.
Living near a Major Road in Beijing: Association with Lower Lung Function, Airway Acidification, and Chronic Cough.
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居住在北京主干道附近：与低肺功能、气道酸化和慢性咳嗽的关系
DOI：
10.4103/0366-6999.189923
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发表时间：
2016-09-20
影响因子：
6.1
通讯作者：
Wang GF
中科院分区：
文献类型：
--
作者：
Hu ZW;Zhao YN;Cheng Y;Guo CY;Wang X;Li N;Liu JQ;Kang H;Xia GG;Hu P;Zhang PJ;Ma J;Liu Y;Zhang C;Su L;Wang GF
背景：在中国，近路污染对肺功能的影响尚未得到很好的研究。我们的目的是调查长期暴露于交通相关的空气污染对肺功能，气道炎症和呼吸道症状的影响。方法：对北京市什刹海社区1003名居民进行调查，年龄57.96 ± 8.99岁。测量家庭地址和最近的主要道路之间的距离，以计算家庭-道路距离。我们使用距离类别1、2和3，分别代表<100 m、100-200 m和>200 m，作为交通相关空气污染暴露的剂量指标。检测肺功能、呼出气冷凝液（EBC）pH值和白细胞介素6水平。作为随访，398名参与者在大约3年后进行了第二次肺功能评估，肺功能下降也作为一项结果进行了检查。我们使用回归分析来评估回家路上的距离对肺功能和呼吸道症状的影响。由于EBC生物标志物数据不是正态分布的，我们进行了回家-道路距离类别和EBC生物标志物之间的相关性分析。结果：居住在离主要道路较近的受试者的1秒用力呼气量预测值百分比较低（FEV1%-1.54，95%置信区间[CI]：-0.20至-2.89）。与3类相比，1类和2类慢性咳嗽的比值比分别为2.54（95% CI：1.57-4.10）和1.97（95% CI：1.16-3.37）。EBC pH值与道路距离呈正相关（等级相关系数斯皮尔曼[rs] = 0.176，P < 0.001）。结论：居住在北京主要道路附近的人长期暴露于与交通相关的空气污染与肺功能降低、气道酸化和慢性咳嗽患病率较高有关。EBC pH值是评价空气污染暴露的潜在有用生物标志物。
Background:The effects of near-road pollution on lung function in China have not been well studied. We aimed to investigate the effects of long-term exposure to traffic-related air pollution on lung function, airway inflammation, and respiratory symptoms. Methods:We enrolled 1003 residents aged 57.96 ± 8.99 years living in the Shichahai Community in Beijing. Distances between home addresses and the nearest major roads were measured to calculate home-road distance. We used the distance categories 1, 2, and 3, representing <100 m, 100–200 m, and >200 m, respectively, as the dose indicator for traffic-related air pollution exposure. Lung function, exhaled breath condensate (EBC) pH, and interleukin 6 levels were measured. As a follow-up, 398 participants had a second lung function assessment about 3 years later, and lung function decline was also examined as an outcome. We used regression analysis to assess the impacts of home-road distance on lung function and respiratory symptoms. As the EBC biomarker data were not normally distributed, we performed correlation analysis between home-road distance categories and EBC biomarkers. Results:Participants living a shorter distance from major roads had lower percentage of predicted value of forced expiratory volume in 1 s (FEV1% −1.54, 95% confidence interval [CI]: −0.20 to −2.89). The odds ratio for chronic cough was 2.54 (95% CI: 1.57–4.10) for category 1 and 1.97 (95% CI: 1.16–3.37) for category 2, compared with category 3. EBC pH was positively correlated with road distance (rank correlation coefficient of Spearman [rs] = 0.176, P < 0.001). Conclusions:Long-term exposure to traffic-related air pollution in people who live near major roads in Beijing is associated with lower lung function, airway acidification, and a higher prevalence of chronic cough. EBC pH is a potential useful biomarker for evaluating air pollution exposure.
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影响因子：
5.8
作者：
Schikowski T;Sugiri D;Ranft U;Gehring U;Heinrich J;Wichmann HE;Krämer U
通讯作者：
Krämer U
影响因子：
4.9
作者：
Atkinson RW;Carey IM;Kent AJ;van Staa TP;Anderson HR;Cook DG
通讯作者：
Cook DG
DOI：
10.6061/clinics/2013(12)03
发表时间：
2013-12
期刊：
Clinics (Sao Paulo, Brazil)
影响因子：
--
作者：
Lima TM;Kazama CM;Koczulla AR;Hiemstra PS;Macchione M;Fernandes AL;Santos Ude P;Bueno-Garcia ML;Zanetta DM;André CD;Saldiva PH;Nakagawa NK
通讯作者：
Nakagawa NK
DOI：
10.1164/ajrccm.155.1.9001300
发表时间：
1997-01-01
影响因子：
24.7
作者：
AckermannLiebrich, U;Leuenberger, P;Zemp, E
通讯作者：
Zemp, E
DOI：
10.1164/rccm.201407-1314oc
发表时间：
2015-08-15
影响因子：
24.7
作者：
Brunst, Kelly J.;Ryan, Patrick H.;LeMasters, Grace
通讯作者：
LeMasters, Grace