The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer.
The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer.
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DOI：
10.1016/j.bbcan.2019.04.001
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发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
Sharma D
中科院分区：
文献类型：
--
作者：
Parida S;Sharma D
乳腺癌的不同发生率仍然是一个有趣的问题，因为只有一小部分具有已知风险因素的女性会患上癌症。最近的研究表明，局部和远处的微生物群在乳腺癌的发生、进展和总体预后中起着积极的作用。益生菌群通过诱导遗传不稳定，启动DNA损伤和受损后代的增殖，引发有利的免疫反应，代谢失调和对治疗的反应改变，使身体易患癌症。在这篇综述中，我们介绍了我们对现有数据集的分析，并讨论了在乳腺癌患者中观察到的局部生态失调，以及可能受局部乳房微生物群影响的乳腺癌发生的不同方面。与健康个体相比，乳腺癌患者乳腺癌中微生物群落组成存在显著差异。在良性和恶性疾病之间以及健康个体和乳房幸存者的乳头抽吸液之间，微生物组的差异也很明显。我们还讨论了乳腺癌的不同细菌，真菌，病毒和寄生虫特征的鉴定。这些微生物能够产生许多次生代谢物，这些代谢物可以作为影响乳腺癌进展的信号介质。我们回顾了微生物如何潜在地改变对药物代谢、药代动力学、抗肿瘤作用和毒性的治疗反应。总之，乳腺癌中有一个微生物群落，可以与宿主细胞交流，诱导下游信号通路，调节乳腺癌生长和转移进展的各个方面，提高对微生物生态失调的理解可能会降低乳腺癌的风险，改善乳腺癌患者的预后。现在被称为“被遗忘的器官”的人类微生物组包含的宏基因组的多样性是人类基因组的100倍，因此与人类健康密切相关。随着人类微生物组计划的启示和深度测序技术的出现，近年来已经获得了大量的信息。曾经被认为是无菌的身体部位，如胃、膀胱和肺，现在被认为是数以百万计的本地微生物物种的避难所。大约80%的健康微生物组由厚壁菌门和拟杆菌门组成，并伴有疣菌门、放线菌门、变形菌门、微内菌门和蓝藻门。微生物组在糖尿病、肥胖甚至神经退行性疾病中的作用在过去十年中得到了极大的重视，现在已经确定微生物组在许多器官特异性癌症中起着重要作用。
Disparate occurrence of breast cancer remains an intriguing question since only a subset of women with known risk factors develop cancer. Recent studies suggest an active role of local and distant microbiota in breast cancer initiation, progression, and overall prognosis. A dysbiotic microbiota predisposes the body to develop cancer by inducing genetic instability, initiating DNA damage and proliferation of the damaged progeny, eliciting favorable immune response, metabolic dysregulation and altered response to therapy. In this review, we present our analyses of the existing datasets and discuss the local dysbiosis observed in breast cancer patients and different aspects of breast carcinogenesis that can be potentially influenced by local breast microbiota. Striking differences between microbial community compositions in breast of cancer patients compared to healthy individuals were noted. Differences in microbiome were also apparent between benign and malignant disease and between nipple aspirate fluid of healthy individuals and breast survivors. We also discuss the identification of distinct bacterial, fungal, viral as well as parasite signatures for breast cancer. These microbes are capable of producing numerous secondary metabolites that can act as signaling mediators effecting breast cancer progression. We review how microbes potentially alter response to therapy affecting drug metabolism, pharmacokinetics, anti-tumor effects and toxicity. In conclusion, breast harbors a community of microbes that can communicate with the host cells inducing downstream signaling pathways and modulating various aspects of breast cancer growth and metastatic progression and an improved understanding of microbial dysbiosis can potentially reduce breast cancer risk and improve outcomes of breast cancer patients. The human microbiome, now referred to as, the “forgotten organ” contains a metagenome that is 100-fold more diverse compared to the human genome, thereby, is critically associated with human health. With the revelations of the human microbiome project and advent of deep sequencing techniques, a plethora of information has been acquired in recent years. Body sites like stomach, bladder and lungs, once thought to be sterile, are now known to harbor millions of indigenous microbial species. Approximately 80% of the healthy microbiome consists of Firmicutes and Bacteroidetes accompanied by Verrucomicrobia, Actinobacteria, Proteobacteria, Tenericutes and Cyanobacteria. The role of microbiome in diabetes, obesity and even neurodegenerative diseases was greatly appreciated in the last decade and now it has been established that microbiome significantly contributes to many organ specific cancers.
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影响因子：
4.6
作者：
Chan AA;Bashir M;Rivas MN;Duvall K;Sieling PA;Pieber TR;Vaishampayan PA;Love SM;Lee DJ
通讯作者：
Lee DJ
影响因子：
7.3
作者：
de Matos-Neto EM;Lima JD;de Pereira WO;Figuerêdo RG;Riccardi DM;Radloff K;das Neves RX;Camargo RG;Maximiano LF;Tokeshi F;Otoch JP;Goldszmid R;Câmara NO;Trinchieri G;de Alcântara PS;Seelaender M
通讯作者：
Seelaender M
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
56.9
作者：
Das, Suman K.;Eder, Sandra;Hoefler, Gerald
通讯作者：
Hoefler, Gerald
影响因子：
9.7
作者：
DUNCAN, AMV;RONEN, A;BLAKEY, DH
通讯作者：
BLAKEY, DH