Regulation of lung inflammation by adiponectin.
Regulation of lung inflammation by adiponectin.
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DOI：
10.3389/fimmu.2023.1244586
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发表时间：
2023
影响因子：
7.3
通讯作者：
Templeton, Steven P.
中科院分区：
文献类型：
--
作者：
Lim, Joo-Yeon;Templeton, Steven P.
关键词：
脂联素是一种胰岛素增敏激素，也在炎症调节中发挥作用。虽然脂联素可以发挥促炎作用，但更多的研究报道了抗炎作用，即使在非脂肪组织如肺中也是如此。肥胖被认为是一种炎症性疾病，是肺部疾病的危险因素，并与血浆脂联素水平降低有关。最近的研究结果表明，脂联素在慢性阻塞性肺疾病、哮喘和侵袭性真菌感染中发挥抗炎活性。脂联素的信号受体AdipoR1和AdipoR2由肺中的上皮细胞、内皮细胞和免疫细胞表达。本文就脂联素在肺细胞和肺组织中的抗炎机制作一综述。
Adiponectin is an insulin sensitizing hormone that also plays a role in the regulation of inflammation. Although adiponectin can exert pro-inflammatory effects, more studies have reported anti-inflammatory effects, even in non-adipose tissues such as the lung. Obesity is considered an inflammatory disease, is a risk factor for lung diseases, and is associated with decreased levels of plasma adiponectin. The results of recent studies have suggested that adiponectin exerts anti-inflammatory activity in chronic obstructive pulmonary disease, asthma and invasive fungal infection. The signaling receptors of adiponectin, AdipoR1 and AdipoR2, are expressed by epithelial cells, endothelial cells, and immune cells in the lung. In this mini-review, we discuss the anti-inflammatory mechanisms of adiponectin in lung cells and tissues.
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