Quantifying Deaths from Aspergillosis in HIV Positive People.
Quantifying Deaths from Aspergillosis in HIV Positive People.
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DOI：
10.3390/jof8111131
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发表时间：
2022-10-27
期刊：
影响因子：
4.7
通讯作者：
Morgan, Ellen Frances
中科院分区：
文献类型：
--
作者：
Denning, David W.;Morgan, Ellen Frances
曲霉是普遍存在的，并引起严重的感染免疫功能低下的病人。对其在HIV/AIDS患者中的发病率和预后了解较少。我们回顾了侵袭性曲霉病在HIV/AIDS患者中的死亡率。使用Pubmed， Embase和Medline数据库搜索文章。如果研究包含其他曲霉病危险因素，没有原始数据或患者生存数据，或者不是英文的，则排除。从已发表的747篇文章中，在阅读后确定了54项研究和病例报告，这些研究和病例报告发表于1985年至2021年之间，其中54%的论文在2000年之前报告了来自16个国家的853名患者，没有来自非洲。707名（83%）患者死亡，从诊断到死亡的平均时间为77.5天。21%的死亡病例为死后诊断。法国对242例生命中诊断出的侵袭性曲霉病进行的全国系列研究显示，抗逆转录病毒治疗前3个月死亡率为68%，在采用抗逆转录病毒治疗和伏立康唑治疗后降至31%。39项研究记录了CD4计数，范围从2到1000个细胞/mm3；仅有8例（1.8%）患者CD4细胞/mm3为100个。曲霉病发生在艾滋病毒/艾滋病患者中，与高死亡率相关，但其进展缓慢，应允许诊断和治疗，并改善结果。
Aspergillus spp. are ubiquitous and cause severe infections in immunocompromised patients. Less is known about its incidence and prognosis in patients with HIV/AIDS. We reviewed the mortality of invasive aspergillosis in HIV/AIDS patients. Pubmed, Embase and Medline databases were used to search for articles. Studies were excluded if they contained other aspergillosis risk factors, no original or patient survival data or were not in English. From 747 articles published, 54 studies and case reports were identified following reading, published between 1985 and 2021, with 54% papers prior to 2000 reporting 853 patients from 16 countries, none from Africa. 707 (83%) patients died with an average time from diagnosis to death of 77.5 days. Postmortem diagnosis was seen in 21% of deaths recorded. A national series from France of 242 cases of invasive aspergillosis diagnosed in life recorded a 3 month mortality of 68% pre-ART, falling to 31% after introduction of ART and voriconazole. CD4 count was recorded in 39 studies and ranged from 2 to >1000 cells/mm3; only 8 patients (1.8%) had a CD4 > 100 cells/mm3. Aspergillosis occurs in patients with HIV/AIDS and associated with high mortality but its slow progression should allow diagnosis and treatment with improved outcome.
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影响因子：
4.7
作者：
Ekeng, Bassey E.;Davies, Adeyinka A.;Osaigbovo, Iriagbonse I.;Warris, Adilia;Oladele, Rita O.;Denning, David W.
通讯作者：
Denning, David W.
影响因子：
1.8
作者：
Arunga, Simon;Kintoki, Guyguy M.;Burton, Matthew J.
通讯作者：
Burton, Matthew J.
影响因子：
3.3
作者：
Barry, S M;Lipman, M C;Prentice, H G
通讯作者：
Prentice, H G
影响因子：
2.8
作者：
Azovtseva, Olga V.;Viktorova, Elena A.
通讯作者：
Viktorova, Elena A.
DOI：
10.1007/bf01649459
发表时间：
1991-11-15
期刊：
KLINISCHE WOCHENSCHRIFT
影响因子：
--
作者：
BONATZ, K;WEISS, A;HEINE, M
通讯作者：
HEINE, M