G protein-coupled receptors: what a difference a 'partner' makes.
G protein-coupled receptors: what a difference a 'partner' makes.
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DOI：
10.3390/ijms15011112
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发表时间：
2014-01-16
影响因子：
5.6
通讯作者：
Cottrell GS
中科院分区：
文献类型：
--
作者：
Roux BT;Cottrell GS
G蛋白偶联受体（gpcr）是重要的细胞信号介质，参与重要的生理过程。GPCRs响应各种各样的配体，从轻到大分子，包括激素和小肽。不幸的是，gpcr的突变和失调会导致功能丧失或表达改变，有时会导致致命的疾病。因此，GPCRs的表达、转运、信号转导和脱敏必须受到不同细胞系统的严格调控才能预防疾病。尽管对调控gpcr脱敏和下调的机制有大量的了解，但对调控新合成的gpcr转运和细胞表面表达的机制知之甚少。最近，越来越多的证据表明，某些gpcr能够与特定的蛋白质相互作用，从而完全改变它们的命运和功能。这些相互作用增加了不同组织/细胞类型之间的另一层次的调节和灵活性。在这里，我们回顾了GPCRs的一些主要相互作用蛋白。更好地了解调节它们相互作用的机制可能会导致新的药物治疗靶点的发现。
G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in essential physiological processes. GPCRs respond to a wide variety of ligands from light to large macromolecules, including hormones and small peptides. Unfortunately, mutations and dysregulation of GPCRs that induce a loss of function or alter expression can lead to disorders that are sometimes lethal. Therefore, the expression, trafficking, signaling and desensitization of GPCRs must be tightly regulated by different cellular systems to prevent disease. Although there is substantial knowledge regarding the mechanisms that regulate the desensitization and down-regulation of GPCRs, less is known about the mechanisms that regulate the trafficking and cell-surface expression of newly synthesized GPCRs. More recently, there is accumulating evidence that suggests certain GPCRs are able to interact with specific proteins that can completely change their fate and function. These interactions add on another level of regulation and flexibility between different tissue/cell-types. Here, we review some of the main interacting proteins of GPCRs. A greater understanding of the mechanisms regulating their interactions may lead to the discovery of new drug targets for therapy.
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影响因子：
4.8
作者：
Aiyar, N;Rand, K;Li, Y
通讯作者：
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影响因子：
3.7
作者：
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DOI：
10.1073/pnas.83.9.2797
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通讯作者：
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