Polysialic acid on the surface of axons regulates patterns of normal and activity-dependent innervation
Polysialic acid on the surface of axons regulates patterns of normal and activity-dependent innervation
复制标题
轴突表面的聚唾液酸调节正常和活动依赖性神经支配的模式
DOI：
10.1016/0166-2236(91)90006-g
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发表时间：
1991
影响因子：
15.9
通讯作者：
L. Landmesser
中科院分区：
文献类型：
--
作者：
U. Rutishauser;L. Landmesser
Studies of the cell--cell adhesion molecules NCAM and L1 have indicated that their combined action is an important determinant in establishing normal patterns of muscle innervation. Moreover, they participate in activity-dependent changes in axonal sprouting. Recent findings in vivo, however, suggest that the central variable in both events is not altered NCAM or L1 expression, but rather changes in the amount of polysialic acid (PSA) at the cell surface. This finding is consistent with the proposed role of PSA as a regulator of cell-cell interactions. Because these molecular entities are present in most of the nervous system, it is likely that this mechanism can influence many aspects of axonal behavior during development and regeneration.The ability of axons to bundle and branch in highly stereotyped patterns is one of the most widespread and remarkable aspects of neuronal specificity. This process facilitates the orderly collection of axons from one tissue, their concerted growth to one or more target regions, and an effective dispersal over that target. Because axon bundling represents a form of regulated cell-cell adhesion, considerable attention has been paid to the identification of adhesion
影响因子：
2.7
作者：
LANDMESSER, L;DAHM, L;RUTISHAUSER, U
通讯作者：
RUTISHAUSER, U
影响因子：
56.9
作者：
RUTISHAUSER, U;ACHESON, A;SUNSHINE, J
通讯作者：
SUNSHINE, J
轴突生长和突触发生过程中 NCAM 在雏鸡后肢的分布。
影响因子：
2.7
作者：
Tosney,KW;Watanabe,M;Landmesser,L;Rutishauser,U
通讯作者：
Rutishauser,U