Maternal High Fat Diet Consumption Exaggerates Metabolic Disorders in Mice With Cigarette-Smoking Induced Intrauterine Undernutrition.
Maternal High Fat Diet Consumption Exaggerates Metabolic Disorders in Mice With Cigarette-Smoking Induced Intrauterine Undernutrition.
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DOI：
10.3389/fnut.2021.638576
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发表时间：
2021
影响因子：
5
通讯作者：
Yi C
中科院分区：
文献类型：
--
作者：
Huang T;Yang M;Zeng Y;Huang X;Wang N;Chen Y;Li P;Yuan J;Chen C;Oliver BG;Yi C
目的：孕妇吸烟导致胎儿发育不良，导致胎儿因宫内营养不良而小于胎龄，导致成年后各种代谢紊乱。此外，产后高脂肪饮食（HFD）消费也是一个强有力的肥胖因素，它可以与母亲吸烟相互作用。在本研究中，我们的目的是确定孕妇在怀孕期间食用高脂脂肪酸是否可以逆转孕妇吸烟的不利影响，并改变产后食用高脂脂肪酸的反应。方法：雌性小鼠在交配前暴露于香烟烟雾（SE， 2支/天）或假暴露5周，其中一半的SE鼠喂食HFD（43%脂肪，SE+HFD）。同样的治疗在整个妊娠期和哺乳期继续进行。每一母组的雄性后代在断奶后饲喂相同的HFD或chow，并在13周时处死。结果：母亲单独SE会增加HFD喂养后代的体重和脂肪量，而SE+HFD喂养的后代在成年期表现出最高的能量摄入和糖代谢紊乱。此外，产后HFD增加了体重，加重了母体SE和SE+HFD引起的代谢紊乱。结论：母体食用高脂肪食物不能改善母体SE的不良反应，反而会加重成年后代的代谢紊乱。怀孕期间需要戒烟和健康饮食，以优化后代的健康结果。
Objectives: Maternal smoking causes fetal underdevelopment and results in births which are small for gestation age due to intrauterine undernutrition, leading to various metabolic disorders in adulthood. Furthermore, postnatal high fat diet (HFD) consumption is also a potent obesogenic factor, which can interact with maternal smoking. In this study, we aimed to determine whether maternal HFD consumption during pregnancy can reverse the adverse impact of maternal smoking and change the response to postnatal HFD consumption. Methods: Female mice were exposed to cigarette smoke (SE, 2 cigarettes/day) or sham exposed for 5 weeks before mating, with half of the SE dams fed HFD (43% fat, SE+HFD). The same treatment continued throughout gestation and lactation. Male offspring from each maternal group were fed the same HFD or chow after weaning and sacrificed at 13 weeks. Results: Maternal SE alone increased body weight and fat mass in HFD-fed offspring, while SE+HFD offspring showed the highest energy intake and glucose metabolic disorder in adulthood. In addition, postnatal HFD increased the body weight and aggravated the metabolic disorder caused by maternal SE and SE+HFD. Conclusions: Maternal HFD consumption could not ameliorate the adverse effect of maternal SE but exaggerate metabolic disorders in adult offspring. Smoking cessation and a healthy diet are needed during pregnancy to optimize the health outcome in the offspring.
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影响因子：
5.6
作者：
Chen H;Saad S;Sandow SL;Bertrand PP
通讯作者：
Bertrand PP
影响因子：
7.4
作者：
Bruin, Jennifer E.;Petre, Maria A.;Holloway, Alison C.
通讯作者：
Holloway, Alison C.
影响因子：
4.8
作者：
Chen, Hui;Simar, David;Morris, Margaret J.
通讯作者：
Morris, Margaret J.
DOI：
10.1016/s0002-9378(16)32790-9
发表时间：
1980-01-01
影响因子：
9.8
作者：
HAWORTH, JC;ELLESTADSAYED, JJ;DILLING, LA
通讯作者：
DILLING, LA
DOI：
10.1093/toxsci/kfq103
发表时间：
2010-08
期刊：
Toxicological sciences : an official journal of the Society of Toxicology
影响因子：
--
作者：
Bruin JE;Gerstein HC;Holloway AC
通讯作者：
Holloway AC