Long-term consequences of fetal and neonatal nicotine exposure: a critical review.
Long-term consequences of fetal and neonatal nicotine exposure: a critical review.
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DOI：
10.1093/toxsci/kfq103
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Holloway AC
中科院分区：
文献类型：
--
作者：
Bruin JE;Gerstein HC;Holloway AC
怀孕期间吸烟与许多产科，胎儿和发育并发症有关，以及成年后代不良健康后果的风险增加。尼古丁替代疗法（NRT）已被开发为戒烟的药物疗法，被认为是女性在怀孕期间吸烟的更安全的替代方案。在有限数量的短期人体试验中评价了妊娠期间使用NRT的安全性，但目前尚无关于人类发育中尼古丁暴露的长期影响的信息。然而，动物研究表明，尼古丁本身可能是一种关键的化学物质，与母亲吸烟对后代的许多长期影响有关，如生育能力受损，2型糖尿病，肥胖，高血压，神经行为缺陷和呼吸功能障碍。本综述将研究胎儿和新生儿尼古丁暴露对产后健康的长期影响。
Cigarette smoking during pregnancy is associated with numerous obstetrical, fetal, and developmental complications, as well as an increased risk of adverse health consequences in the adult offspring. Nicotine replacement therapy (NRT) has been developed as a pharmacotherapy for smoking cessation and is considered to be a safer alternative for women to smoking during pregnancy. The safety of NRT use during pregnancy has been evaluated in a limited number of short-term human trials, but there is currently no information on the long-term effects of developmental nicotine exposure in humans. However, animal studies suggest that nicotine alone may be a key chemical responsible for many of the long-term effects associated with maternal cigarette smoking on the offspring, such as impaired fertility, type 2 diabetes, obesity, hypertension, neurobehavioral defects, and respiratory dysfunction. This review will examine the long-term effects of fetal and neonatal nicotine exposure on postnatal health.
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