Endothelial progenitor cells: quo vadis?
Endothelial progenitor cells: quo vadis?
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DOI：
10.1016/j.yjmcc.2010.07.009
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发表时间：
2011-02
影响因子：
5
通讯作者：
Yoder MC
中科院分区：
文献类型：
--
作者：
Richardson MR;Yoder MC
术语内皮祖细胞(EPC)是指在体外表现出与内皮细胞相似的细胞表面抗原，在缺血或血管损伤区域循环和停留，并根据组织需要促进受损血管的修复或促进新血管发育的循环细胞。在第一份报告发表10多年后，术语EPC被用来指一系列表现出上述某些或全部特性的循环细胞，然而，基本上所有的细胞现在都被认为是造血系的成员。例外的是一种罕见的具有克隆性增殖能力的循环内皮细胞，它在植入免疫缺陷的小鼠宿主组织后显示出自发形成融合人类血管的能力。本文将回顾当前所有称为EPC的细胞之间的谱系关系，并将提出术语EPC被淘汰，并根据每个子集已经存在的术语来指代每个循环细胞子集。本文是题为“心血管干细胞回顾”的特刊的一部分。
The term endothelial progenitor cell (EPC) was coined to refer to circulating cells that displayed the ability to display cell surface antigens similar to endothelial cells in vitro, to circulate and lodge in areas of ischemia or vascular injury, and to facilitate the repair of damaged blood vessels or augment development of new vessels as needed by a tissue. More than 10 years after the first report, the term EPC is used to refer to a host of circulating cells that display some or all of the qualities indicated above, however, essentially all of the cells are now known to be members of the hematopoietic lineage. The exception is a rare viable circulating endothelial cell with clonal proliferative potential that displays the ability to spontaneously form inosculating human blood vessels upon implantation into immunodeficient murine host tissues. This paper will review the current lineage relationships among all the cells called EPC and will propose that the term EPC be retired and that each of the circulating cell subsets be referred to according to the terms already existent for each subset. This article is part of a special issue entitled, "Cardiovascular Stem Cells Revisited".
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