The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease.
The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease.
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DOI：
10.1186/gb-2005-6-2-209
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发表时间：
2005
期刊：
影响因子：
12.3
通讯作者：
Zachary I
中科院分区：
文献类型：
--
作者：
Holmes DI;Zachary I
血管内皮生长因子（VEGF）是一类结构高度保守的多肽家族。在哺乳动物中，VEGF在血管发育、淋巴管发育和疾病相关的血管生成中发挥作用，VEGF样分子及其受体在无血管系统的简单无脊椎动物中的存在表明，该生长因子家族在多细胞生物进化的非常早期阶段就出现了，以介导原始发育功能。血管内皮生长因子（Vascular endothelial growth factors，VEGF）是一类具有高度保守的受体结合胱氨酸结结构的分泌性多肽，与血小板源性生长因子相似。VEGF-A是该家族的创始成员，在鱼类和哺乳动物等进化上遥远的动物之间高度保守。在脊椎动物中，VEGF通过内皮细胞中的同源受体激酶家族起作用以刺激血管形成。VEGF-A在哺乳动物血管发育和涉及血管异常生长的疾病中具有重要作用;其他VEGF也参与淋巴管的发育和疾病相关的血管生成。VEGF和VEGF受体的无脊椎动物同源物已在苍蝇、线虫和水母中鉴定，它们在发育细胞迁移和神经发生中起作用。VEGF样分子及其受体在没有血管系统的简单无脊椎动物中的存在表明，这个生长因子家族在多细胞生物进化的早期阶段就出现了，以介导原始发育功能。
Vascular endothelial growth factors (VEGFs) are a family of polypeptides with a highly conserved structure. In mammals, VEGFs have roles in vascular development, development of lymphatic vessels and disease-related angiogenesis.The existence of VEGF-like molecules and their receptors in simple invertebrates without a vascular system indicates that this family of growth factors emerged at a very early stage in the evolution of multicellular organisms to mediate primordial developmental functions. Vascular endothelial growth factors (VEGFs) are a family of secreted polypeptides with a highly conserved receptor-binding cystine-knot structure similar to that of the platelet-derived growth factors. VEGF-A, the founding member of the family, is highly conserved between animals as evolutionarily distant as fish and mammals. In vertebrates, VEGFs act through a family of cognate receptor kinases in endothelial cells to stimulate blood-vessel formation. VEGF-A has important roles in mammalian vascular development and in diseases involving abnormal growth of blood vessels; other VEGFs are also involved in the development of lymphatic vessels and disease-related angiogenesis. Invertebrate homologs of VEGFs and VEGF receptors have been identified in fly, nematode and jellyfish, where they function in developmental cell migration and neurogenesis. The existence of VEGF-like molecules and their receptors in simple invertebrates without a vascular system indicates that this family of growth factors emerged at a very early stage in the evolution of multicellular organisms to mediate primordial developmental functions.
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DOI：
10.1073/pnas.95.24.14389
发表时间：
1998-11-24
影响因子：
11.1
作者：
Cao, YH;Linden, P;Alitalo, K
通讯作者：
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影响因子：
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影响因子：
4.8
作者：
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