The Zebrafish Information Network: the zebrafish model organism database provides expanded support for genotypes and phenotypes.

The Zebrafish Information Network: the zebrafish model organism database provides expanded support for genotypes and phenotypes.
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DOI:
10.1093/nar/gkm956
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发表时间:
2008-01
影响因子:
14.9
通讯作者:
Westerfield M
Westerfield M
中科院分区:
生物学2区
文献类型:
--
作者:
Sprague J;Bayraktaroglu L;Bradford Y;Conlin T;Dunn N;Fashena D;Frazer K;Haendel M;Howe DG;Knight J;Mani P;Moxon SA;Pich C;Ramachandran S;Schaper K;Segerdell E;Shao X;Singer A;Song P;Sprunger B;Van Slyke CE;Westerfield M

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斑马鱼信息网(http://zfin.org),)是斑马鱼的模式生物数据库,为斑马鱼的遗传、基因组和发育数据提供了中心位置。突变表型、基因、表达模式、序列、遗传标记、吗啉、地图位置、出版物和群落资源的广泛数据集成促进了斑马鱼作为研究基因功能、发育、行为和疾病的模型的使用。对ZFIN数据的访问是通过基于网络的查询表格和大量数据文件提供的。ZFIN是斑马鱼基因和等位基因命名法、斑马鱼解剖本体论(AO)和斑马鱼基因本体论(GO)注释的权威来源。ZFIN在表型质量本体论(PATO)和基因本体论(GO)等跨物种本体论的发展中发挥着积极的作用。ZFIN最近的改进包括:(I)一个新的主页和导航栏,(Ii)扩大了对基因型和表型的支持,(Iii)基于解剖、表型质量和基因本体论的全面的表型注释,(Iv)通过ZFIN特有的数据集与ZFIN数据库紧密集成的BLAST服务器,(V)全球站点搜索和(Vi)实践资源帮助。
The Zebrafish Information Network (ZFIN, http://zfin.org), the model organism database for zebrafish, provides the central location for curated zebrafish genetic, genomic and developmental data. Extensive data integration of mutant phenotypes, genes, expression patterns, sequences, genetic markers, morpholinos, map positions, publications and community resources facilitates the use of the zebrafish as a model for studying gene function, development, behavior and disease. Access to ZFIN data is provided via web-based query forms and through bulk data files. ZFIN is the definitive source for zebrafish gene and allele nomenclature, the zebrafish anatomical ontology (AO) and for zebrafish gene ontology (GO) annotations. ZFIN plays an active role in the development of cross-species ontologies such as the phenotypic quality ontology (PATO) and the gene ontology (GO). Recent enhancements to ZFIN include (i) a new home page and navigation bar, (ii) expanded support for genotypes and phenotypes, (iii) comprehensive phenotype annotations based on anatomical, phenotypic quality and gene ontologies, (iv) a BLAST server tightly integrated with the ZFIN database via ZFIN-specific datasets, (v) a global site search and (vi) help with hands-on resources.
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