Engineering living functional materials.
Engineering living functional materials.
复制标题
DOI：
10.1021/sb500113b
复制
发表时间：
2015-01-16
影响因子：
4.7
通讯作者：
Lu, Timothy K.
中科院分区：
文献类型：
--
作者：
Chen, Allen Y.;Zhong, Chao;Lu, Timothy K.
天然材料，如骨，将由有机分子组成的活细胞与无机成分结合在一起。这使得功能的组合，如机械强度和再生和重塑的能力，这是不存在于现有的合成材料。从大自然中得到启示，我们提出，工程化的“生命功能材料”和“生命材料合成平台”，结合了生命系统和无机成分，可以改变材料的性能和制造。作为概念验证，我们最近证明了大肠杆菌中的合成基因电路使生物膜本身既是一种功能材料，也是一种材料合成平台。为了证明前者，我们设计了E。大肠杆菌的生物膜变成了一个化学诱导物响应的电子开关。为了证明后者，我们设计了E。大肠杆菌生物膜以动态地组织跨多个长度尺度的生物-非生物材料、模板金纳米棒、金纳米线和金属/半导体异质结构，并合成半导体纳米颗粒（Chen，A. Y.等（2014）用工程细胞合成和图案化可调多尺度材料。Nat.Mater.13，515-523.）。因此，合成生物学的工具，如人工基因调控的工具，可以用来设计生命系统的时空特征，并将生命系统与无机材料连接起来。这样的杂化物可以具有由活细胞实现的新特性，同时保留无机系统的期望功能。这些系统，作为活的功能材料和活的材料铸造厂，将提供一个完全不同的材料性能和合成材料的范例，这些材料具有多功能，自我修复，适应性和可进化的特性，这些特性是以分布式，自下而上，自主组装和环境可持续的方式创建和组织的。
Natural materials, such as bone, integrate living cells composed of organic molecules together with inorganic components. This enables combinations of functionalities, such as mechanical strength and the ability to regenerate and remodel, which are not present in existing synthetic materials. Taking a cue from nature, we propose that engineered ‘living functional materials’ and ‘living materials synthesis platforms’ that incorporate both living systems and inorganic components could transform the performance and the manufacturing of materials. As a proof-of-concept, we recently demonstrated that synthetic gene circuits in Escherichia coli enabled biofilms to be both a functional material in its own right and a materials-synthesis platform. To demonstrate the former, we engineered E. coli biofilms into a chemical-inducer-responsive electrical switch. To demonstrate the latter, we engineered E. coli biofilms to dynamically organize biotic-abiotic materials across multiple length scales, template gold nanorods, gold nanowires, and metal/semiconductor heterostructures, and synthesize semiconductor nanoparticles (Chen, A. Y. et al. (2014) Synthesis and patterning of tunable multiscale materials with engineered cells. Nat. Mater.13, 515–523.). Thus, tools from synthetic biology, such as those for artificial gene regulation, can be used to engineer the spatiotemporal characteristics of living systems and to interface living systems with inorganic materials. Such hybrids can possess novel properties enabled by living cells while retaining desirable functionalities of inorganic systems. These systems, as living functional materials and as living materials foundries, would provide a radically different paradigm of materials performance and synthesis–materials possessing multifunctional, self-healing, adaptable, and evolvable properties that are created and organized in a distributed, bottom-up, autonomously assembled, and environmentally sustainable manner.
登录
查看更多内容
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
19
作者：
Liu, Jennifer S.;Gartner, Zev J.
通讯作者：
Gartner, Zev J.
影响因子：
64.8
作者：
Wang HH;Isaacs FJ;Carr PA;Sun ZZ;Xu G;Forest CR;Church GM
通讯作者：
Church GM
影响因子：
5.5
作者：
Rice MK;Ruder WC
通讯作者：
Ruder WC
影响因子：
56.9
作者：
Lee, Yun Jung;Yi, Hyunjung;Belcher, Angela M.
通讯作者：
Belcher, Angela M.