Validation of plasma metabolites associated with breast cancer risk among Mexican Americans.
Validation of plasma metabolites associated with breast cancer risk among Mexican Americans.
复制标题
墨西哥裔美国人中与乳腺癌风险相关的血浆代谢物的验证。
DOI：
10.1016/j.canep.2020.101826
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发表时间：
2020-12
影响因子：
2.6
通讯作者：
Chow WH
中科院分区：
文献类型：
--
作者：
Zhao H;Shen J;Ye Y;Wu X;Esteva FJ;Tripathy D;Chow WH
在我们之前的拉美裔乳腺癌病例对照研究中，我们发现了14种代谢物，它们的水平在病例和对照之间存在差异。为了验证结果，我们对100例乳腺癌患者和100名来自墨西哥裔美国人队列研究的匹配的健康女性进行了嵌套病例对照研究。调整胎次、教育程度、出生地、语言文化、BMI类别、吸烟、饮酒、体力活动、坐着时间等因素后，有4种代谢产物与乳腺癌相关：3-羟基辛酸酯(OR=1.51，95%可信区间：1.10，3.47)，3-羟基丁酸酯(OR=1.42，95%CI：1.01，3.72)，亚油酸(18：2n6)(OR=1.39，95%CI：1.07，4.04)，胆红素(OR=0.54，0.54)。95%可信区间：0.42，0.95)。然后，我们使用3种非冗余代谢物，即3-羟基辛酸、亚油酸(18：2n6)和胆红素来生成代谢风险评分。代谢物风险评分增加与乳腺癌风险增加1.67倍相关(OR=1.67，95%CI：1.32，3.94)。在那些在随访期间(≤5年)较早被诊断为癌症的人中，这种显著的关联比他们的同龄人更明显。总之，我们确定了四种重要的代谢物，它们可能有助于阐明导致乳腺癌发生的代谢途径。我们的发现为进一步的复制工作提供了保证。
In our previous breast cancer case control study in Hispanics, we found 14 metabolites whose levels differed between cases and controls. To validate the results, we carried out a nested case control study of 100 incident breast cancer and 100 matched healthy women identified from the Mano-A-Mano Mexican American Cohort study. With the adjustment of parity, education, birth place, language acculturation, BMI category, smoking, drinking, physical activity, and sitting time, 4 metabolites were associated with breast cancer risk: 3-hydroxyoctanoate (Odds ratio (OR)=1.51, 95% confidence interval (CI): 1.10, 3.47), 3-hydroxybutyrate (BHBA) (OR=1.42, 95%CI: 1.01, 3.72), linoleate (18:2n6) (OR =1.39, 95% CI: 1.07, 4.04), and bilirubin (OR=0.54, 95%CI: 0.42, 0.95). Then, we used 3 non-redundant metabolites, namely 3-hydroxyoctanoate, linoleate (18:2n6), and bilirubin, to generate a metabolic risk score. Increased metabolites risk score was associated with a 1.67-fold increased risk of breast cancer (OR =1.67, 95%CI: 1.32, 3.94). And the significant association was more evident among those who were diagnosed with cancer earlier during the follow-up (≤ 5 years) than their counterparts. In conclusion, we identified four significant metabolites which may help elucidate metabolic pathways that contribute to breast carcinogenesis. Our findings warrant further replication efforts.
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影响因子：
2.3
作者：
Temme, EHM;Zhang, JJ;Kesteloot, H
通讯作者：
Kesteloot, H
JAK/STAT3调节的脂肪酸β-氧化对于乳腺癌干细胞的自我更新和化学抗性至关重要。
影响因子：
29
作者：
Wang T;Fahrmann JF;Lee H;Li YJ;Tripathi SC;Yue C;Zhang C;Lifshitz V;Song J;Yuan Y;Somlo G;Jandial R;Ann D;Hanash S;Jove R;Yu H
通讯作者：
Yu H
DOI：
10.1158/1078-0432.ccr-14-0748
发表时间：
2015-01-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Wen CP;Zhang F;Liang D;Wen C;Gu J;Skinner H;Chow WH;Ye Y;Pu X;Hildebrandt MA;Huang M;Chen CH;Hsiung CA;Tsai MK;Tsao CK;Lippman SM;Wu X
通讯作者：
Wu X
影响因子：
5.4
作者：
Zhang H;Zhou L;Shi W;Song N;Yu K;Gu Y
通讯作者：
Gu Y
影响因子：
7.7
作者：
Chow, Wong-Ho;Chrisman, Matthew;Wu, Xifeng
通讯作者：
Wu, Xifeng