Greater cognitive reserve is related to lower cortical excitability in healthy cognitive aging, but not in early clinical Alzheimer's disease.
Greater cognitive reserve is related to lower cortical excitability in healthy cognitive aging, but not in early clinical Alzheimer's disease.
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在健康的认知衰老过程中，较高的认知储备与较低的皮质兴奋性有关，但在早期临床阿尔茨海默病中并非如此。
DOI：
10.3389/fnhum.2023.1193407
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发表时间：
2023
影响因子：
2.9
通讯作者：
中科院分区：
文献类型：
--
作者：
研究认知未受损的老年人（CU）以及患有阿尔茨海默病（AD）导致的轻度认知障碍或轻度痴呆的老年人的皮质运动兴奋性与认知储备（CR）之间的关系。
收集并分析了15名认知未受损者和24名年龄在50 - 90岁的淀粉样蛋白阳性的AD参与者的数据。认知储备问卷评分（CRQ）评估了教育程度、职业、休闲活动、体育活动和社会参与情况。皮质兴奋性通过对初级运动皮层施加单脉冲经颅磁刺激所诱发的运动诱发电位的平均幅度（MEP幅度）来量化。一个线性模型比较了各组之间的MEP幅度。一个线性模型测试了CRQ对所有参与者的MEP幅度的影响。最后，分别用线性模型测试了CRQ对每组内MEP幅度的影响。探索性分析使用嵌套回归分析测试了每组内人口统计学特征、认知评分、萎缩指标和脑脊液指标的影响修正情况。
在考虑协变量后，MEP幅度在组间没有差异。主要模型显示组*CRQ存在显著的交互项（调整后的R² = 0.18，p = 0.013），但CRQ没有主效应。在认知未受损组内，较高的CRQ与较低的MEP幅度显著相关（调整后的R² = 0.45，p = 0.004）。在AD组中没有相关性。
在认知未受损者中，较低的皮质运动兴奋性与较高的CRQ有关，但在AD患者中并非如此。较低的MEP幅度可能反映了认知未受损的老年人具有更高的神经效率。在AD参与者中未观察到相关性可能反映了认知储备的保护作用被破坏。未来需要进一步研究以更好地理解在患有和未患有神经退行性疾病的老年人中导致认知储备保护作用的神经生理机制。
To investigate the relationship between cortico-motor excitability and cognitive reserve (CR) in cognitively unimpaired older adults (CU) and in older adults with mild cognitive impairment or mild dementia due to Alzheimer’s disease (AD). Data were collected and analyzed from 15 CU and 24 amyloid-positive AD participants aged 50–90 years. A cognitive reserve questionnaire score (CRQ) assessed education, occupation, leisure activities, physical activities, and social engagement. Cortical excitability was quantified as the average amplitude of motor evoked potentials (MEP amplitude) elicited with single-pulse transcranial magnetic stimulation delivered to primary motor cortex. A linear model compared MEP amplitudes between groups. A linear model tested for an effect of CRQ on MEP amplitude across all participants. Finally, separate linear models tested for an effect of CRQ on MEP amplitude within each group. Exploratory analyses tested for effect modification of demographics, cognitive scores, atrophy measures, and CSF measures within each group using nested regression analysis. There was no between-group difference in MEP amplitude after accounting for covariates. The primary model showed a significant interaction term of group*CRQ (R2adj = 0.18, p = 0.013), but no main effect of CRQ. Within the CU group, higher CRQ was significantly associated with lower MEP amplitude (R2adj = 0.45, p = 0.004). There was no association in the AD group. Lower cortico-motor excitability is related to greater CRQ in CU, but not in AD. Lower MEP amplitudes may reflect greater neural efficiency in cognitively unimpaired older adults. The lack of association seen in AD participants may reflect disruption of the protective effects of CR. Future work is needed to better understand the neurophysiologic mechanisms leading to the protective effects of CR in older adults with and without neurodegenerative disorders.
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影响因子：
4.2
作者：
Buss SS;Press DZ;McDonald K;Kitchener E;O'Connor M;Donohoe K;Shafi MM;Pascual-Leone A;Fried PJ
通讯作者：
Fried PJ
影响因子：
9.9
作者：
Doraiswamy, P. Murali;Sperling, Reisa A.;Pontecorvo, Michael J.
通讯作者：
Pontecorvo, Michael J.
影响因子：
7.2
作者：
Austin, Peter C.;Steyerberg, Ewout W.
通讯作者：
Steyerberg, Ewout W.
影响因子：
3.8
作者：
Habeck, Christian;Gazes, Yunglin;Stern, Yaakov
通讯作者：
Stern, Yaakov
影响因子：
4.8
作者：
Ferreri F;Guerra A;Vollero L;Ponzo D;Määtta S;Könönen M;Vecchio F;Pasqualetti P;Miraglia F;Simonelli I;Corbetta M;Rossini PM
通讯作者：
Rossini PM