TMS-EEG Biomarkers of Amnestic Mild Cognitive Impairment Due to Alzheimer's Disease: A Proof-of-Concept Six Years Prospective Study.
TMS-EEG Biomarkers of Amnestic Mild Cognitive Impairment Due to Alzheimer's Disease: A Proof-of-Concept Six Years Prospective Study.
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TMS-EEG生物标志物的遗忘轻度认知障碍由于阿尔茨海默病：概念验证六年前瞻性研究。
DOI：
10.3389/fnagi.2021.737281
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发表时间：
2021
影响因子：
4.8
通讯作者：
Rossini PM
中科院分区：
文献类型：
--
作者：
Ferreri F;Guerra A;Vollero L;Ponzo D;Määtta S;Könönen M;Vecchio F;Pasqualetti P;Miraglia F;Simonelli I;Corbetta M;Rossini PM
背景资料：早期和负担得起的鉴定患有遗忘型轻度认知障碍（aMCI）的将转化为阿尔茨海默病（AD）的受试者是一个重大的科学挑战。目的：研究aMCI患者感觉运动皮层功能的神经生理学特征，假设其中一些可能代表神经变性诱导的可塑性重排，因此是未来转化为AD的预测因子。我们试图确定（1）感觉运动网络是否在aMCI患者中显示出特殊的改变，以及（2）感觉运动网络改变是否在个体水平上预测长期疾病进展。研究方法：我们研究了一组aMCI患者感觉运动皮层的几个经颅磁刺激（TMS）-脑电图（EEG）参数，并随访了6年。然后，我们确定了临床转化为AD的aMCI [前驱期转化为AD-MCI（pAD-MCI）]和认知保持稳定的人[非前驱期转化为AD-MCI（npAD-MCI）]。结果如下：与对照受试者相比，aMCI患者表现出运动皮层（M1）兴奋性降低，α、β和γ频段的EEG同步性中断[试验间相干性降低（ITC）]。pAD-MCI和npAD-MCI之间M1兴奋性和α ITC的改变程度相当。重要的是，pAD-MCI中刺激M1的β和γ ITC损伤大于npAD-MCI。此外，与头皮信号的波形形状相关的附加参数，反映了全局TMS诱导的活动[偶极活动（sDA）的稳定性]的时间特异性改变，将npAD-MCI与将转化为AD的MCI区分开来。讨论内容：上述特定的皮质变化反映了aMCI中皮质-基底节-丘脑-皮质环内的同步化缺陷，可能反映了AD的病理过程。这些变化可以作为AD的神经生理学生物标志物在更大的队列中进行测试。
Background: Early and affordable identification of subjects with amnestic mild cognitive impairment (aMCI) who will convert to Alzheimer’s disease (AD) is a major scientific challenge. Objective: To investigate the neurophysiological hallmarks of sensorimotor cortex function in aMCI under the hypothesis that some may represent the plastic rearrangements induced by neurodegeneration, hence predictors of future conversion to AD. We sought to determine (1) whether the sensorimotor network shows peculiar alterations in patients with aMCI and (2) if sensorimotor network alterations predict long-term disease progression at the individual level. Methods: We studied several transcranial magnetic stimulation (TMS)-electroencephalogram (EEG) parameters of the sensorimotor cortex in a group of patients with aMCI and followed them for 6 years. We then identified aMCI who clinically converted to AD [prodromal to AD-MCI (pAD-MCI)] and those who remained cognitively stable [non-prodromal to AD-MCI (npAD-MCI)]. Results: Patients with aMCI showed reduced motor cortex (M1) excitability and disrupted EEG synchronization [decreased intertrial coherence (ITC)] in alpha, beta and gamma frequency bands compared to the control subjects. The degree of alteration in M1 excitability and alpha ITC was comparable between pAD-MCI and npAD-MCI. Importantly, beta and gamma ITC impairment in the stimulated M1 was greater in pAD-MCI than npAD-MCI. Furthermore, an additional parameter related to the waveform shape of scalp signals, reflecting time-specific alterations in global TMS-induced activity [stability of the dipolar activity (sDA)], discriminated npAD-MCI from MCI who will convert to AD. Discussion: The above mentioned specific cortical changes, reflecting deficit of synchronization within the cortico-basal ganglia-thalamo-cortical loop in aMCI, may reflect the pathological processes underlying AD. These changes could be tested in larger cohorts as neurophysiological biomarkers of AD.
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影响因子：
4.3
作者：
de Haan W;Mott K;van Straaten EC;Scheltens P;Stam CJ
通讯作者：
Stam CJ
影响因子：
4.8
作者：
Ferreri, Florinda;Vecchio, Fabrizio;Di Lazzaro, Vincenzo
通讯作者：
Di Lazzaro, Vincenzo
影响因子：
4.1
作者：
Ferreri, Florinda;Rossini, Paolo Maria
通讯作者：
Rossini, Paolo Maria
影响因子：
9
作者：
Benussi, Alberto;Alberici, Antonella;Borroni, Barbara
通讯作者：
Borroni, Barbara
影响因子：
3.3
作者：
Bologna, Matteo;Guerra, Andrea;Berardelli, Alfredo
通讯作者：
Berardelli, Alfredo