Evolutionary Principles of Bacterial Signaling Capacity and Complexity.
Evolutionary Principles of Bacterial Signaling Capacity and Complexity.
复制标题
细菌信号传导能力和复杂性的进化原理
作者：
微生物依靠信号转导系统来感知和响应环境变化以生存和繁殖。众所周知，生态位适应在形成信号库中起着重要作用。然而，细菌信号转导能力的进化缺乏系统的研究与时间的方向。特别是，对于信令网络，复杂性如何从简单性演变而来，反之亦然，目前还不清楚。在此，我们研究了弯曲菌门（Campylobacterota，前身为Epsilonproteobacteria）中主要信号转导系统的进化过程，弯曲菌门是一个具有足够进化深度和生态多样性的门。我们发现，化学感受系统通过水平基因转移（HGT）增加了整个化学感受类的复杂性，不同的化学感受类很少混合它们的组件。非典型组氨酸激酶与受体结构域融合，实现多步或分支的信号转导过程，使双组分系统变得复杂。c-di-GMP介导的系统的存在和复杂性与信号网络的大小有关，并且c-di-GMP途径易于重新布线，因为酶和效应物可以在没有直接蛋白质-蛋白质相互作用的情况下连接。总体而言，弯曲菌的信号传导能力和复杂性同时上升和下降，这取决于感官需求、遗传资源和基因组环境中的协同进化。这些发现反映了其他细胞网络和细菌结构域基因组进化的合理进化原理。
Microbes rely on signal transduction systems to sense and respond to environmental changes for survival and reproduction. It is generally known that niche adaptation plays an important role in shaping the signaling repertoire. However, the evolution of bacterial signaling capacity lacks systematic studies with a temporal direction. In particular, it is unclear how complexity evolved from simplicity or vice versa for signaling networks. Here, we examine the evolutionary processes of major signal transduction systems in Campylobacterota (formerly Epsilonproteobacteria), a phylum with sufficient evolutionary depth and ecological diversity. We discovered that chemosensory system increases complexity by horizontal gene transfer (HGT) of entire chemosensory classes, and different chemosensory classes rarely mix their components. Two-component system gains complexity by atypical histidine kinases fused with receiver domain to achieve multistep or branched signal transduction process. The presence and complexity of c-di-GMP-mediated system is related to the size of signaling network, and c-di-GMP pathways are easy to rewire, since enzymes and effectors can be linked without direct protein-protein interaction. Overall, signaling capacity and complexity rise and drop together in Campylobacterota, determined by sensory demand, genetic resources, and coevolution within the genomic context. These findings reflect plausible evolutionary principles for other cellular networks and genome evolution of the Bacteria domain.
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影响因子：
10.5
作者：
Dahlstrom KM;O'Toole GA
通讯作者：
O'Toole GA
影响因子：
14.9
作者：
Casas-Pastor D;Müller RR;Jaenicke S;Brinkrolf K;Becker A;Buttner MJ;Gross CA;Mascher T;Goesmann A;Fritz G
通讯作者：
Fritz G
影响因子：
4.2
作者：
Galperin MY
通讯作者：
Galperin MY
影响因子：
--
作者：
Gabler, Felix;Nam, Seung-Zin;Alva, Vikram
通讯作者：
Alva, Vikram
DOI：
10.1101/sqb.1965.030.01.030
发表时间：
1965-01-01
期刊：
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY
影响因子：
--
作者：
ADLER, J
通讯作者：
ADLER, J