A census of membrane-bound and intracellular signal transduction proteins in bacteria: bacterial IQ, extroverts and introverts.
A census of membrane-bound and intracellular signal transduction proteins in bacteria: bacterial IQ, extroverts and introverts.
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DOI：
10.1186/1471-2180-5-35
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发表时间：
2005-06-14
期刊：
影响因子：
4.2
通讯作者：
Galperin MY
中科院分区：
文献类型：
--
作者：
Galperin MY
对完整微生物基因组的分析表明，会影响编码相对原始信号系统的稳定生态壁ches的细胞内寄生虫和其他微生物，而环境微生物通常具有环境传感和信号转导的复杂系统。
本文介绍了信号转导蛋白的全面人口普查 - 组氨酸激酶，甲基接受的趋化受体，Ser/Thr/Thr/Tyr/Tyr蛋白激酶，腺苷酸化和二烷基化循环以及C-DI-GMP磷酸二酯酶 - 编码在167个细菌和古老的基因组中，在2004年底之前进行了测序。已手动检查数据，以避免在大规模自动化期间通常出现的假阴性和假阳性命中与其他可用资源进行了分析。根据功率定律分布，其他信号传感器在某些系统发育群体中很丰富，但实际上在其他系统中不存在。
信号系统的复杂性即使在紧密相关的生物之间也有所不同，通常可以与生物体的系统发育位置，其生活方式和典型的环境挑战相关。蛋白质集）可以用作衡量生物体适应潜水条件的能力，即“细菌IQ”，而跨膜受体与细胞内传感器可用于定义生物是“外向”，积极地感知环境参数，还是“内向的”，更关心其内部稳态。在研究较差的β-β-和epsilon-甲状腺细菌中发现。他们使用复杂的细胞内膜系统进行氧合光合作用的能力，可用于使用AT的人口普查数据。顺序。
Analysis of complete microbial genomes showed that intracellular parasites and other microorganisms that inhabit stable ecological niches encode relatively primitive signaling systems, whereas environmental microorganisms typically have sophisticated systems of environmental sensing and signal transduction. This paper presents results of a comprehensive census of signal transduction proteins – histidine kinases, methyl-accepting chemotaxis receptors, Ser/Thr/Tyr protein kinases, adenylate and diguanylate cyclases and c-di-GMP phosphodiesterases – encoded in 167 bacterial and archaeal genomes, sequenced by the end of 2004. The data have been manually checked to avoid false-negative and false-positive hits that commonly arise during large-scale automated analyses and compared against other available resources. The census data show uneven distribution of most signaling proteins among bacterial and archaeal phyla. The total number of signal transduction proteins grows approximately as a square of genome size. While histidine kinases are found in representatives of all phyla and are distributed according to the power law, other signal transducers are abundant in certain phylogenetic groups but virtually absent in others. The complexity of signaling systems differs even among closely related organisms. Still, it usually can be correlated with the phylogenetic position of the organism, its lifestyle, and typical environmental challenges it encounters. The number of encoded signal transducers (or their fraction in the total protein set) can be used as a measure of the organism's ability to adapt to diverse conditions, the 'bacterial IQ', while the ratio of transmembrane receptors to intracellular sensors can be used to define whether the organism is an 'extrovert', actively sensing the environmental parameters, or an 'introvert', more concerned about its internal homeostasis. Some of the microorganisms with the highest IQ, including the current leader Wolinella succinogenes, are found among the poorly studied beta-, delta- and epsilon-proteobacteria. Among all bacterial phyla, only cyanobacteria appear to be true introverts, probably due to their capacity to conduct oxygenic photosynthesis, using a complex system of intracellular membranes. The census data, available at , can be used to get an insight into metabolic and behavioral propensities of each given organism and improve prediction of the organism's properties based solely on its genome sequence.
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影响因子：
2.9
作者：
Delgado-Nixon, VM;Gonzalez, G;Gilles-Gonzalez, MA
通讯作者：
Gilles-Gonzalez, MA
影响因子：
1.2
作者：
Bardy, S;Ng, SYM;Jarrell, KF
通讯作者：
Jarrell, KF
影响因子：
2.1
作者：
Ashby, MK
通讯作者：
Ashby, MK
DOI：
10.1073/pnas.1932838100
发表时间：
2003-09-30
影响因子：
11.1
作者：
Baar, C;Eppinger, M;Schuster, SC
通讯作者：
Schuster, SC
影响因子：
3.2
作者：
Brooun, A;Zhang, WS;Alam, M
通讯作者：
Alam, M