Black tea and mammary gland carcinogenesis by 7,12-dimethylbenz[a]anthracene in rats fed control or high fat diets.
Black tea and mammary gland carcinogenesis by 7,12-dimethylbenz[a]anthracene in rats fed control or high fat diets.
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红茶和 7,12-二甲基苯并[a]蒽对饲喂对照或高脂肪饮食的大鼠的乳腺致癌作用。
作者：
Adrianne E. Rogers;Laurie J. Hafer;Yvette S. Iskander;Shi Yang
流行病学研究表明，茶可以降低癌症风险，在实验室啮齿动物中，茶或茶纯化提取物的化学预防作用已在肺，胃肠道和皮肤中得到证实。有一些证据表明茶在乳腺中具有化学预防作用，但数据并不确定。为了更全面地评价红茶对7，12-二甲基苯并[a]蒽（DMBA）诱发的雌性S-D乳腺肿瘤的可能影响，（Sprague-Dawley）大鼠，进行了三项大型研究：实验1，在大鼠中的肿瘤发生，所述大鼠喂食AIN-76 A饮食并给予25 mg/kg DMBA和1.25或2.5%全茶提取物或饮用水;实验2，给予15 mg/kg DMBA和与实验1相同的饮食和液体的大鼠的肿瘤发生;实验3，给予15 mg/kg DMBA和2%茶或水饮用的对照或HF（高脂肪，玉米油）饮食的大鼠的肿瘤发生。在整个实验过程中给予茶;在8周龄时通过胃管饲给予DMBA。在喂食AIN-76 A饮食的大鼠中，茶对肿瘤发生没有一致的影响;然而，在实验3中有证据表明，在喂食HF饮食的大鼠中，茶减少了肿瘤发生。在实验3中，与喂食对照饲料的大鼠相比，喂食HF饲料并给予水的大鼠显示出预期的肿瘤负荷（数量和重量）增加。然而，喂食HF饮食和给予2%茶的大鼠显示肿瘤负荷没有增加;它们的肿瘤负荷显著低于喂食HF饮食和给予水的大鼠（P < 0.01），并且与喂食对照饮食和给予水或茶的大鼠没有差异。此外，在实验3中，HF饮食使饮水大鼠的每只荷瘤大鼠的恶性肿瘤数增加（P < 0.01），但对饮茶大鼠没有影响。因此，茶似乎部分阻断了HF饮食对DMBA诱导的乳腺肿瘤发生的促进作用。
Epidemiological studies suggest that tea may reduce cancer risk, and in laboratory rodents, chemopreventive effects of tea or purified extracts of tea have been demonstrated in lung, gastrointestinal tract and skin. There is some evidence of chemoprevention by tea in the mammary gland, but the data are not conclusive. In order to evaluate more fully the possible influence of black tea on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary gland tumors in the female S-D (Sprague-Dawley) rat, three large studies were performed: experiment 1, tumorigenesis in rats fed AIN-76A diet and given 25 mg/kg DMBA and 1.25 or 2.5% whole tea extract or water to drink; experiment 2, tumorigenesis in rats given 15 mg/kg DMBA and the same diet and fluids as in experiment 1; experiment 3, tumorigenesis in rats fed control or HF (high fat, corn oil) diet and given 15 mg/kg DMBA and 2% tea or water to drink. Tea was given throughout the experiment; DMBA was given by gastric gavage at 8 weeks of age. There was no consistent effect of tea on tumorigenesis in rats fed AIN-76A diet; there was, however, evidence in experiment 3 of a reduction of tumorigenesis by tea in rats fed the HF diet. In experiment 3, rats fed the HF diet and given water showed the expected increase in tumor burden (number and weight) compared with rats fed control diet. However, rats fed the HF diet and given 2% tea showed no increase in tumor burden; their tumor burden was significantly lower than in rats fed the HF diet and given water (P < 0.01) and was not different from rats fed control diet and given water or tea. In addition, in experiment 3, the number of malignant tumors per tumor-bearing rat was increased by the HF diet in water-drinking rats (P < 0.01) but not in tea-drinking rats. Therefore, it appears that tea partially blocked the promotion of DMBA-induced mammary tumorigenesis by the HF diet.
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摄入含有标准和高水平不饱和脂肪的化学限定饮食的雌性大鼠中，咖啡因摄入量对 7,12-二甲基苯并（a）蒽诱导的乳腺肿瘤发生的影响。
影响因子：
11.2
作者：
Welsch,CW;DeHoog,JV
通讯作者：
DeHoog,JV
根据激素受体状态的膳食脂肪和乳腺癌风险。
DOI：
--
发表时间：
1995
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Kushi,LH;Potter,JD;Bostick,RM;Drinkard,CR;Sellers,TA;Gapstur,SM;Cerhan,JR;Folsom,AR
通讯作者：
Folsom,AR
影响因子：
5
作者：
Zheng, W;Doyle, TJ;Folsom, AR
通讯作者：
Folsom, AR
影响因子：
9.7
作者：
LIAO, SS;UMEKITA, Y;HIIPAKKA, RA
通讯作者：
HIIPAKKA, RA
茶对动物模型和人类致癌的影响。
影响因子：
--
作者：
Yang,CS;Chen,L;Lee,MJ;Landau,JM
通讯作者：
Landau,JM