Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury.
Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury.
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DOI：
10.1371/journal.pone.0066314
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Epstein JA
中科院分区：
文献类型：
--
作者：
Takeda N;Jain R;Li D;Li L;Lu MM;Epstein JA
味蕾由多种味觉受体细胞组成，这些细胞从舌上皮发育而来，在正常的体内平衡条件下以及损伤后定期补充。引起味蕾再生的细胞的特征知之甚少。最近的研究表明，Lgr5（富含亮氨酸重复的G蛋白偶联受体5）识别味蕾干细胞，有助于成年人的轮廓和叶状味觉乳头（位于舌头的后部区域）的稳态再生。成年人舌前部的味觉乳头不表达Lgr5。在这里，我们证实和扩展这些研究表明，LGR 5细胞在发展过程中产生前和后味蕾，并能够再生后味蕾损伤诱导的舌咽神经横断。
Taste buds are composed of a variety of taste receptor cell types that develop from tongue epithelium and are regularly replenished under normal homeostatic conditions as well as after injury. The characteristics of cells that give rise to regenerating taste buds are poorly understood. Recent studies have suggested that Lgr5 (leucine-rich repeat-containing G-protein coupled receptor 5) identifies taste bud stem cells that contribute to homeostatic regeneration in adult circumvallate and foliate taste papillae, which are located in the posterior region of the tongue. Taste papillae in the adult anterior region of the tongue do not express Lgr5. Here, we confirm and extend these studies by demonstrating that Lgr5 cells give rise to both anterior and posterior taste buds during development, and are capable of regenerating posterior taste buds after injury induced by glossopharyngeal nerve transection.
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影响因子：
5.3
作者：
Morita, H;Mazerbourg, S;Hsueh, AJW
通讯作者：
Hsueh, AJW
影响因子：
1.5
作者：
Gaillard, Dany;Barlow, Linda A.
通讯作者：
Barlow, Linda A.
影响因子：
25
作者：
Madisen L;Zwingman TA;Sunkin SM;Oh SW;Zariwala HA;Gu H;Ng LL;Palmiter RD;Hawrylycz MJ;Jones AR;Lein ES;Zeng H
通讯作者：
Zeng H
DOI：
10.1634/stemcells.2008-0611
发表时间：
2009-02
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Okubo T;Clark C;Hogan BL
通讯作者：
Hogan BL
DOI：
10.1073/pnas.0607399104
发表时间：
2007-02-13
影响因子：
11.1
作者：
Iwatsuki, Ken;Liu, Hong-Xiang;Margolskee, Robert F.
通讯作者：
Margolskee, Robert F.