Influence of breathing route on upper airway lining liquid surface tension in humans
Influence of breathing route on upper airway lining liquid surface tension in humans
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呼吸路径对人体上呼吸道内层液体表面张力的影响
DOI：
10.1113/jphysiol.2005.102129
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
J. Kirkness
中科院分区：
文献类型：
--
作者：
M. Verma;M. Seto‐Poon;J. Wheatley;T. Amis;J. Kirkness
我们最近证实，阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者睡眠障碍呼吸的严重程度可以通过降低上呼吸道衬里液体的表面张力(γ)来减轻。大多数OSAHS患者都报告了晨口干燥症(与睡眠中的口腔呼吸有关)。在本研究中，我们研究了呼吸途径、口腔粘膜“湿度”和UAL的γ之间的关系。我们研究了8名健康受试者(年龄，25±5岁[平均±5岁]；体重指数，23±2 kg m−2)，分别在不同的一天(随机)进行120min的鼻式呼吸(张口式呼吸)和单纯口式呼吸(鼻夹)。每隔15分钟测量一次口腔粘膜‘湿润度’(5 S接触重量吸收纸片法)和γ(‘拉离’力法)，每15分钟测量一次(取下口腔胶带并根据需要更换)。μL取自咽后壁的UAL0.2例，每隔15分钟测量一次。鼻腔呼吸120分钟内，上呼吸道粘膜湿润度从4.0±0.4(平均值±S.E.M.)L(5 S)μ−1由4.5±0.4降至0.1±0.2μL(S 5)−1(P&t；0.001，重复测量方差分析，图基多重比较检验，后验检验)。同时，UAL的γ在鼻呼吸时由5 9.3±2.2降至5 1.8±0.98mN m−1，而在口呼吸时由64.4±2.7升至77.4±1.1mM−1(P<0.001)。对于受试者和研究的所有情况，UAL值的γ与上呼吸道粘膜‘湿度’强烈相关(相关系数，R2=−0.34，P<；0.001；线性回归)。我们的结论是，健康受试者清醒时，口呼吸增加，鼻呼吸减少UAL的γ。我们推测OSAHS患者在睡眠期间的鼻呼吸可能促进了UAL的低γ，这可能有助于减轻睡眠障碍呼吸的严重程度。
We have recently demonstrated that the severity of sleep‐disordered breathing in obstructive sleep apnoea hypopnoea syndrome (OSAHS) can be reduced by lowering the surface tension (γ) of the upper airway lining liquid (UAL). Morning xerostomia (related to oral breathing during sleep) is reported by most OSAHS patients. In the present study we examine relationships between breathing route, oral mucosal ‘wetness’ and the γ of UAL. We studied eight healthy subjects (age, 25 ± 5 years [mean ±s.d.]; body‐mass index, 23 ± 2 kg m−2) during a 120 min challenge of both nasal‐only breathing (mouth taped) and oral‐only breathing (nose clip), each on a separate day (randomized). Both oral mucosal ‘wetness’ (5 s contact gravimetric absorbent paper strip method) and the γ (‘pull‐off’ force technique) of 0.2 μl samples of UAL obtained from the posterior pharyngeal wall were measured at 15 min intervals (mouth tape removed and replaced as required). Upper airway mucosal ‘wetness’ increased during 120 min of nasal breathing from 4.0 ± 0.4 (mean ±s.e.m.) to 5.3 ± 0.3 μl (5 s)−1 but decreased from 4.5 ± 0.4 to 0.1 ± 0.2 μl (5 s)−1 with oral breathing (both P < 0.001, repeated‐measures ANOVA, Tukey's multiple comparison test, post hoc test). Concurrently, the γ of UAL decreased from 59.3 ± 2.2 to 51.8 ± 0.98 mN m−1 with nasal breathing but increased from 64.4 ± 2.7 to 77.4 ± 1.1 mN m−1 with oral breathing (P < 0.001). For the group and all conditions studied, γ of UAL values strongly correlated with upper airway mucosal ‘wetness’ (correlation coefficient, r2=−0.34, P < 0.001; linear regression). We conclude that oral breathing increases and nasal breathing decreases the γ of UAL in healthy subjects during wakefulness. We speculate that nasal breathing in OSAHS patients during sleep may promote a low γ of UAL that may contribute to reducing the severity of sleep‐disordered breathing.
DOI：
10.1177/10454411930040030101
发表时间：
1993-01-01
期刊：
CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE
影响因子：
--
作者：
LAMKIN, MS;OPPENHEIM, FG
通讯作者：
OPPENHEIM, FG
影响因子：
3.3
作者：
BASNER, RC;SIMON, PM;WEISS, JW
通讯作者：
WEISS, JW