Which early life events or current environmental and lifestyle factors influence lung function in adolescents? - results from the GINIplus & LISAplus studies.
Which early life events or current environmental and lifestyle factors influence lung function in adolescents? - results from the GINIplus & LISAplus studies.
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DOI：
10.1186/s12931-017-0619-5
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发表时间：
2017-07-12
影响因子：
5.8
通讯作者：
Schulz H
中科院分区：
文献类型：
--
作者：
Luzak A;Fuertes E;Flexeder C;Standl M;von Berg A;Berdel D;Koletzko S;Heinrich J;Nowak D;Schulz H
在人生的不同阶段，各种因素可能影响肺功能。由于同时考虑几个因素的调查很少，我们研究了早期生活、当前环境/生活方式因素和过敏性疾病对15岁青少年肺功能的相对重要性。对1326名德国GINIplus和LISAplus出生队列的参与者进行线性回归模型的最佳亚群选择，以研究21种不同的早期生活事件与当前因素与肺活量参数（用力肺活量、1s内用力呼气量和最大呼气中流量（FEF25-75））之间的关系。为了降低模型复杂性，在随机亚群（N = 884）中对每个肺活量测定参数的一个模型重复1000次。只有那些包含在bbb70 %复制模型中的因素在最终分析中被保留。较高的峰值体重速度和早期肺部感染是与气流限制和FEF25-75普遍相关的早期生活事件。当前15岁时与肺功能相关的环境/生活方式因素和过敏性疾病有：室内二手烟暴露、维生素D浓度、体重指数（BMI）和哮喘状况。性别和身高占据了解释方差的大部分（约75%），其次是BMI（≤23.7%）。早期生活事件解释的方差相对较低（中位数：4.8%；范围：0.2-22.4%），但这些事件始终与气道功能呈负相关。虽然解释的差异主要是由肺功能预测方程中包含的众所周知的因素所捕获，但我们的研究结果表明，在青少年肺健康研究中应该考虑早期生活和当前的因素。本文的在线版本（doi:10.1186/s12931-017-0619-5）包含补充材料，可供授权用户使用。
Various factors may affect lung function at different stages in life. Since investigations that simultaneously consider several factors are rare, we examined the relative importance of early life, current environmental/lifestyle factors and allergic diseases on lung function in 15-year-olds. Best subset selection was performed for linear regression models to investigate associations between 21 diverse early life events and current factors with spirometric parameters (forced vital capacity, forced expiratory volume in 1 s and maximal mid-expiratory flow (FEF25–75)) in 1326 participants of the German GINIplus and LISAplus birth cohorts. To reduce model complexity, one model for each spirometric parameter was replicated 1000 times in random subpopulations (N = 884). Only those factors that were included in >70% of the replication models were retained in the final analysis. A higher peak weight velocity and early lung infections were the early life events prevalently associated with airflow limitation and FEF25–75. Current environmental/lifestyle factors at age 15 years and allergic diseases that were associated with lung function were: indoor second-hand smoke exposure, vitamin D concentration, body mass index (BMI) and asthma status. Sex and height captured the majority of the explained variance (>75%), followed by BMI (≤23.7%). The variance explained by early life events was comparatively low (median: 4.8%; range: 0.2–22.4%), but these events were consistently negatively associated with airway function. Although the explained variance was mainly captured by well-known factors included in lung function prediction equations, our findings indicate early life and current factors that should be considered in studies on lung health among adolescents. The online version of this article (doi:10.1186/s12931-017-0619-5) contains supplementary material, which is available to authorized users.
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影响因子：
3.7
作者：
Cibella, Fabio;Bruno, Andreina;Viegi, Giovanni
通讯作者：
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影响因子：
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作者：
den Dekker, Herman T.;Voort, Agnes M. M. Sonnenschein-van der;Duijts, Liesbeth
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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