The fructose tolerance test in patients with chronic kidney disease and metabolic syndrome in comparison to healthy controls.
The fructose tolerance test in patients with chronic kidney disease and metabolic syndrome in comparison to healthy controls.
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DOI：
10.1186/s12882-015-0048-y
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发表时间：
2015-05-03
期刊：
影响因子：
2.3
通讯作者：
Johnson RJ
中科院分区：
文献类型：
--
作者：
Donderski R;Miśkowiec-Wiśniewska I;Kretowicz M;Grajewska M;Manitius J;Kamińska A;Junik R;Siódmiak J;Stefańska A;Odrowąż-Sypniewska G;Pluta A;Lanaspa M;Johnson RJ
果糖会急剧升高正常受试者的血清尿酸，但对代谢综合征或慢性肾病受试者的影响尚不清楚。该研究的目的是评估慢性肾病、代谢综合征患者与健康对照者在果糖耐量试验期间血清尿酸的变化。研究对象包括 36 名患有肥胖症（体重指数 >30）和代谢综合征的受试者、14 名患有 3 期慢性肾病的患者以及 25 名健康志愿者。对每位患者进行果糖耐受性测试。果糖挑战期间血清尿酸的变化与基线动态血压、血清尿酸、代谢和炎症标志物以及靶器官损伤（包括颈动脉内膜中层厚度和肾抵抗指数（通过多普勒测定））相关。慢性肾脏病组的绝对血清尿酸值最高，其次是代谢综合征组，然后是健康对照组。在所有三组中都观察到响应果糖耐量测试的血清尿酸的类似增加，但与其他两组相比，在健康对照中观察到最大百分比的增加。尿酸相对升高与肾脏疾病（白蛋白尿、eGFR）或代谢综合征相关的临床或炎症参数之间没有显示出显着关联。患有慢性肾病和代谢综合征的受试者在果糖耐量测试后具有较高的绝对尿酸值，但血清尿酸的增加百分比相对较小。果糖耐受试验期间血清尿酸的变化与代谢参数、炎症介质或靶器官损伤的变化无关。这些研究表明，果糖引起的血清尿酸的急剧变化并不能预测肥胖、代谢综合征或慢性肾病受试者的代谢表型或炎症介质的存在。该研究已在 ClinicalTrials.gov 上注册。标识符：NCT01332526。 www.register.clinicaltrials.gov/01332526 本文的在线版本 (doi:10.1186/s12882-015-0048-y) 包含补充材料，可供授权用户使用。
Fructose acutely raises serum uric acid in normal subjects, but the effect in subjects with metabolic syndrome or subjects with chronic kidney disease is unknown. The aim of the study was to evaluate changes in serum uric acid during the fructose tolerance test in patients with chronic kidney disease, metabolic syndrome with comparison to healthy controls. Studies were performed in 36 subjects with obesity (body mass index >30) and metabolic syndrome, 14 patients with stage 3 chronic kidney disease, and 25 healthy volunteers. The fructose tolerance test was performed in each patient. The change in serum uric acid during the fructose challenge was correlated with baseline ambulatory blood pressure, serum uric acid, metabolic, and inflammatory markers, and target organ injury including carotid intima media thickness and renal resistive index (determined by Doppler). Absolute serum uric acid values were highest in the chronic kidney disease group, followed by the metabolic syndrome and then healthy controls. Similar increases in serum uric acid in response to the fructose tolerance test was observed in all three groups, but the greatest percent rise was observed in healthy controls compared to the other two groups. No significant association was shown between the relative rise in uric acid and clinical or inflammatory parameters associated with kidney disease (albuminuria, eGFR) or metabolic syndrome. Subjects with chronic kidney disease and metabolic syndrome have higher absolute uric acid values following a fructose tolerance test, but show a relatively smaller percent increase in serum uric acid. Changes in serum uric acid during the fructose tolerance test did not correlate with changes in metabolic parameters, inflammatory mediators or with target organ injury. These studies suggest that acute changes in serum uric acid in response to fructose do not predict the metabolic phenotype or presence of inflammatory mediators in subjects with obesity, metabolic syndrome or chronic kidney disease. The study was registered in ClinicalTrials.gov. Identifier : NCT01332526. www.register.clinicaltrials.gov/01332526 The online version of this article (doi:10.1186/s12882-015-0048-y) contains supplementary material, which is available to authorized users.
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影响因子：
3.3
作者：
Rho, Young Hee;Zhu, Yanyan;Choi, Hyon K.
通讯作者：
Choi, Hyon K.
影响因子：
4.1
作者：
VANDENBERGHE, G;BRONFMAN, M;HERS, HG
通讯作者：
HERS, HG
DOI：
10.3109/00365513.2012.758386
发表时间：
2013-03-01
影响因子：
2.1
作者：
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影响因子：
56.9
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影响因子：
13.6
作者：
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Nakagawa, Takahiko