IL-22 production is regulated by IL-23 during Listeria monocytogenes infection but is not required for bacterial clearance or tissue protection.
IL-22 production is regulated by IL-23 during Listeria monocytogenes infection but is not required for bacterial clearance or tissue protection.
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DOI：
10.1371/journal.pone.0017171
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发表时间：
2011-02-15
期刊：
影响因子：
3.7
通讯作者：
Berg RE
中科院分区：
文献类型：
--
作者：
Graham AC;Carr KD;Sieve AN;Indramohan M;Break TJ;Berg RE
单核细胞增多性李斯特菌(Lm)是一种革兰氏阳性细菌，是加工肉类和乳制品的常见污染物。在人类中，摄入LM会导致脾和肝脏的细胞内感染，最终可能导致败血症、脑膜炎和自然流产。白介素23是一种细胞因子，通过诱导产生IL-17A、IL-17F和IL-22来调节先天和获得性免疫反应。我们最近已经证明，在肺炎衣原体感染期间，中性粒细胞需要IL-23/IL-17轴才能最佳地募集到肝脏，而不是脾。此外，在全身感染期间，这些细胞因子是清除LM所必需的。在其他感染模型中，IL-22诱导抗微生物多肽的分泌，并通过防止细胞凋亡来保护组织免受损害。然而，IL-22在肺炎衣原体感染中的作用还没有得到彻底的研究。在本研究中，我们证明了LM在体内诱导IL-22的产生。有趣的是，IL-23是在原发而不是继发的LM感染过程中产生IL-22所必需的。我们的研究结果表明，无论是全身感染还是粘膜感染，在原发或继发感染过程中，不需要使用IL-22来清除LM。IL-22也不是保护感染了LM的脾和肝脏免受器官损伤所必需的。总而言之，这些数据表明，在LM感染过程中产生的IL-22必须发挥除清除LM或保护组织免受病原体或免疫介导的损害之外的作用。
Listeria monocytogenes (LM) is a gram-positive bacterium that is a common contaminant of processed meats and dairy products. In humans, ingestion of LM can result in intracellular infection of the spleen and liver, which can ultimately lead to septicemia, meningitis, and spontaneous abortion. Interleukin (IL)-23 is a cytokine that regulates innate and adaptive immune responses by inducing the production of IL-17A, IL-17F, and IL-22. We have recently demonstrated that the IL-23/IL-17 axis is required for optimal recruitment of neutrophils to the liver, but not the spleen, during LM infection. Furthermore, these cytokines are required for the clearance of LM during systemic infection. In other infectious models, IL-22 induces the secretion of anti-microbial peptides and protects tissues from damage by preventing apoptosis. However, the role of IL-22 has not been thoroughly investigated during LM infection. In the present study, we show that LM induces the production of IL-22 in vivo. Interestingly, IL-23 is required for the production of IL-22 during primary, but not secondary, LM infection. Our findings suggest that IL-22 is not required for clearance of LM during primary or secondary infection, using both systemic and mucosal models of infection. IL-22 is also not required for the protection of LM infected spleens and livers from organ damage. Collectively, these data indicate that IL-22 produced during LM infection must play a role other than clearance of LM or protection of tissues from pathogen- or immune-mediated damage.
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影响因子：
32.4
作者：
Oppmann, B;Lesley, R;Kastelein, RA
通讯作者：
Kastelein, RA
DOI：
10.1084/jem.20031051
发表时间：
2003-11-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Berg RE;Crossley E;Murray S;Forman J
通讯作者：
Forman J
影响因子：
5.8
作者：
Lecuit, Marc
通讯作者：
Lecuit, Marc
影响因子：
4.4
作者：
Ghilardi, N;Kljavin, N;de Sauvage, FJ
通讯作者：
de Sauvage, FJ
影响因子：
30.5
作者：
Duhen, Thomas;Geiger, Rebekka;Sallusto, Federica
通讯作者：
Sallusto, Federica